School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Kualalampur, Selangor, 47500, Malaysia.
School Of Medicine,Faculty of Health and Medical Sciences, Taylor's University, Kualalampur, Selangor, 47500, Malaysia.
F1000Res. 2020 Aug 4;9:901. doi: 10.12688/f1000research.24866.1. eCollection 2020.
Ovarian cancer is a fatal gynaecological cancer and eighth most common cancer in women globally. Lifestyle, reproductive and sociodemographic factors are among the influential parameters that may significantly affect the risk of ovarian cancer and its mortality rate. However, the epidemiological investigations have shown that the risk of ovarian cancers associated with these factors is different in varied geographical distributions. Lifestyle and reproductive factors have not been investigated thoroughly across a wide cultural diversity. The objective of this study is to investigate the association of these factors with ovarian cancer in Pakistan. This investigation will focus on the lifestyle effects of fat intake, intake of tea, habitual exercise, use of talc, personal hygiene, habit of holding urine for long time, obesity on ovarian cancer among Pakistani women. Reproductive variables will include age at menarche, natural menopausal age, parity, nulliparity (miscarriages, abortion, stillbirths), infertility, fertility treatment, tubal ligation, oral contraceptive use, and family history of breast or ovarian cancer. Sociodemographic variables will include effect of age, income, education, and geographical location. A case-control study will be conducted in the major cancer hospitals of Pakistan and the patients will also be interviewed. The controls will be recruited outside the hospital. For controls the same age limit and residency requirements will be applied. The information gained from this research will be an important contribution to develop programs for health promotion, with a focus on ovarian cancer prevention and women's health. The findings could be used for health policies and planning to prevent ovarian cancer. The research will pave the way for a public policy and interventions to reduce the burden of ovarian cancer in Pakistan.
卵巢癌是一种致命的妇科癌症，也是全球女性中第八种最常见的癌症。生活方式、生殖和社会人口因素是影响卵巢癌风险和死亡率的重要参数。然而，流行病学调查表明，与这些因素相关的卵巢癌风险在不同的地理分布中存在差异。生活方式和生殖因素在广泛的文化多样性中尚未得到充分研究。本研究的目的是调查这些因素与巴基斯坦卵巢癌之间的关联。本研究将重点研究脂肪摄入、饮茶、习惯性运动、滑石粉使用、个人卫生、长时间憋尿、肥胖等生活方式因素对巴基斯坦妇女卵巢癌的影响。生殖变量将包括初潮年龄、自然绝经年龄、产次、不孕、不育治疗、输卵管结扎、口服避孕药使用以及乳腺癌或卵巢癌家族史。社会人口变量将包括年龄、收入、教育和地理位置的影响。将在巴基斯坦主要癌症医院进行病例对照研究，并对患者进行访谈。对照将在医院外招募。对照的年龄限制和居住要求相同。从这项研究中获得的信息将是制定促进健康计划的重要贡献，重点是预防卵巢癌和妇女健康。研究结果可用于制定卫生政策和规划，以预防卵巢癌。该研究将为巴基斯坦制定减少卵巢癌负担的公共政策和干预措施铺平道路。
