Park Chung-Soo, Kim Hyun-Soo, Ahn Yeon-Soon, Ahn Jung-Ho, Jeong Kyoung Sook
Department of Occupational and Environmental Medicine, Ajou University Hospital, Suwon, Korea.
Industrial Health and Work Environment Research Institute, Korean Industrial Health Association, Seoul, Korea.
Ann Occup Environ Med. 2020 Jul 7;32:e24. doi: 10.35371/aoem.2020.32.e24. eCollection 2020.
The International Agency for Research on Cancer classified 1,2-dichloropropane (1,2-DCP) as a human carcinogen in 2016. It is necessary to establish a health monitoring system for workers exposed to 1,2-DCP. We investigated the correlation between 1,2-DCP concentration in air and urine to determine whether it is appropriate to measure 1,2-DCP in urine as a biological exposure index (BEI).
Twenty-seven workers from 3 manufacturing industries handling 1,2-DCP participated in this study. Airborne 1,2-DCP was collected by personal air. Urine samples were collected at the end of work and analyzed using gas chromatography-mass spectrometry. Correlation analysis and simple regression analysis were performed to investigate the relationship between 1,2-DCP concentration in urine and air.
Pearson correlation coefficients between total 1,2-DCP in air and urine (uncorrected, creatinine-corrected) were 0.720 and 0.819, respectively. For urine samples analyzed within 2 weeks, the Spearman's rho of 1,2-DCP concentration in urine (uncorrected and creatinine-corrected) was 0.906 and 0.836, respectively. Simple regression analysis of 1,2-DCP in air and urinary 1,2-DCP concentrations within 2 weeks, which showed the highest correlation, revealed that the coefficient of determination of 1,2-DCP concentration in urine (uncorrected and creatinine-corrected) was 0.801 and 0.784, respectively.
As a BEI for workers exposed to 1,2-DCP, urinary 1,2-DCP without creatinine correction better reflects the exposure levels of 1,2-DCP in air.
国际癌症研究机构于2016年将1,2 - 二氯丙烷（1,2 - DCP）列为人类致癌物。有必要为接触1,2 - DCP的工人建立健康监测系统。我们研究了空气中1,2 - DCP浓度与尿液中1,2 - DCP浓度之间的相关性，以确定将尿液中1,2 - DCP作为生物接触指数（BEI）进行测量是否合适。
来自3个处理1,2 - DCP的制造业的27名工人参与了本研究。通过个人空气采样器收集空气中的1,2 - DCP。在工作结束时收集尿液样本，并使用气相色谱 - 质谱法进行分析。进行相关性分析和简单回归分析以研究尿液中1,2 - DCP浓度与空气中1,2 - DCP浓度之间的关系。
空气中总1,2 - DCP与尿液中1,2 - DCP（未校正、肌酐校正）的Pearson相关系数分别为0.720和0.819。对于在2周内分析的尿液样本，尿液中1,2 - DCP浓度（未校正和肌酐校正）的Spearman秩相关系数分别为0.906和0.836。对空气中1,2 - DCP与2周内尿液中1,2 - DCP浓度进行简单回归分析（相关性最高），结果显示尿液中1,2 - DCP浓度（未校正和肌酐校正）的决定系数分别为0.801和0.784。
作为接触1,2 - DCP工人的生物接触指数，未进行肌酐校正的尿液中1,2 - DCP能更好地反映空气中1,2 - DCP的接触水平。
