Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Department of Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Biomed Res Int. 2020 Aug 4;2020:8105735. doi: 10.1155/2020/8105735. eCollection 2020.
It is widely acknowledged that cancer cell energy metabolism relies mainly on anaerobic glycolysis; this phenomenon is described as the Warburg effect. However, whether the Warburg effect is caused by genetic dysregulation in cancer or is the cause of cancer remains unknown. The exact reasons and physiology of this abnormal metabolism are unclear; therefore, many researchers have attempted to reduce malignant cell growth in tumors in preclinical and clinical studies. Anticancer strategies based on the Warburg effect have involved the use of drug compounds and dietary changes. We recently reviewed applications of the Warburg effect to understand the benefits of this unusual cancer-related metabolism. In the current article, we summarize diet strategies for cancer treatment based on the Warburg effect.
人们普遍认为，癌细胞的能量代谢主要依赖于无氧糖酵解；这种现象被描述为沃伯格效应。然而，沃伯格效应是由癌症中的遗传失调引起的，还是癌症的原因尚不清楚。这种异常代谢的确切原因和生理学机制尚不清楚；因此，许多研究人员试图在临床前和临床研究中减少肿瘤中的恶性细胞生长。基于沃伯格效应的抗癌策略包括使用药物化合物和饮食改变。我们最近回顾了沃伯格效应的应用，以了解这种异常的癌症相关代谢的益处。在本文中，我们总结了基于沃伯格效应的癌症治疗饮食策略。
