LRRK2 拯救受损的内膜系统。
LRRK2 to the rescue of damaged endomembranes.
机构信息
Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
出版信息
EMBO J. 2020 Sep 15;39(18):e106162. doi: 10.15252/embj.2020106162. Epub 2020 Aug 16.
Abstract
Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD-related leucine-rich repeat kinase 2 (LRRK2) is activated in response to pathogen or membranolytic drug-induced damage of phagolysosomes and lysosomes in macrophages, and regulates endolysosomal homeostasis by controlling the balance between membrane repair and degradation.
摘要
几种编码溶酶体蛋白的基因突变与帕金森病（PD）有关。在本期杂志中，Herbst 等人（2020）表明，与 PD 相关的富亮氨酸重复激酶 2（LRRK2）在巨噬细胞的吞噬溶酶体和溶酶体受到病原体或膜溶解药物诱导损伤时被激活，并通过控制膜修复和降解之间的平衡来调节内溶酶体平衡。
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