Park Min-Young, Hwang Shinwon, Chun Soo Il, Kim Su Min, Almurayshid Abdurrahman, Oh Sang Ho
Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Chunsooil Skin Clinic, Seoul, Korea.
Dermatol Surg. 2021 Mar 1;47(3):e101-e105. doi: 10.1097/DSS.0000000000002672.
Fractional microneedle radiofrequency (FMR) and nonablative 1927-nm fractional thulium fiber laser (TFL) are widely used for skin rejuvenation treatment.
To investigate the efficacy and safety of combined treatment with both devices for wrinkles.
Twenty-five patients with wrinkles were enrolled. One side of the face was treated with FMR alone, while the other side was treated with a combination of FMR and TFL. Each treatment consisted of 3 sessions at four-week intervals and patients were followed up 12 weeks after the last treatment. Overall improvement was assessed by patient global assessment (PGA) and investigator global assessment (IGA). Depression scores for the evaluation of wrinkles were objectively assessed by Antera 3D system.
Both sides of the face led to clinical improvement in both mean PGA and IGA. Combination treatment demonstrated a greater improvement in both mean PGA and IGA compared with FMR alone. In addition, wrinkle grading scales and depression scores showed greater improvement in the combination group than in FMR alone.
This study demonstrated that FMR and TFL comprise a good combination treatment for the treatment of wrinkles because both treatments have a synergistic effect on wrinkle improvement.
微针射频（FMR）和非剥脱性1927纳米掺铥光纤激光（TFL）广泛用于皮肤年轻化治疗。
研究两种设备联合治疗皱纹的疗效和安全性。
招募了25名有皱纹的患者。面部一侧仅用FMR治疗，而另一侧用FMR和TFL联合治疗。每次治疗包括3次，间隔4周，患者在最后一次治疗后随访12周。通过患者整体评估（PGA）和研究者整体评估（IGA）评估总体改善情况。通过Antera 3D系统客观评估用于评估皱纹的凹陷评分。
面部两侧的平均PGA和IGA均有临床改善。与单独使用FMR相比，联合治疗在平均PGA和IGA方面均有更大改善。此外，皱纹分级量表和凹陷评分显示联合治疗组比单独使用FMR组有更大改善。
本研究表明，FMR和TFL是治疗皱纹的良好联合治疗方法，因为两种治疗方法对改善皱纹具有协同作用。
