Skin Health Institute and Royal Children's Hospital, Melbourne, Victoria, Australia.
Queensland Centre for Mental Health Research, Brisbane, Australia.
J Burn Care Res. 2021 Mar 4;42(2):200-206. doi: 10.1093/jbcr/iraa130.
Fractional ablative CO2 laser is being used increasingly to treat burn scars; however, objective measures of outcome success vary widely. This systematic review and meta-analysis extracts and pools available data to assess the outcomes of patients with burn scars treated with fractional ablative CO2 laser. A search of MEDLINE, EMBASE, and the gray literature was performed. The review included studies that reported patients with a confirmed diagnosis of scarring as a result of a burn injury, who were treated with fractional ablative CO2 laser and whose progress was recorded using the Vancouver Scar Scale (VSS). Eight studies were included in the systematic review and meta-analysis. Treatment regimens varied amongst studies, as did patient outcomes. Pooled data revealed an average VSS improvement of 29% across 282 patients following fractional CO2 ablative laser treatment. Although the heterogeneity of treatment regimens across studies limits this systematic review's ability to provide specific treatment recommendations, the overall trend towards improvement of burns scars treated with fractional CO2 laser based on the VSS encourages further exploration of this modality as a therapeutic tool.
飞梭式二氧化碳激光正越来越多地用于治疗烧伤疤痕；然而，客观的疗效衡量标准差异很大。本系统回顾和荟萃分析提取并汇集了现有数据，以评估接受飞梭式二氧化碳激光治疗的烧伤疤痕患者的治疗结果。对 MEDLINE、EMBASE 和灰色文献进行了检索。该综述纳入了报告因烧伤而患有疤痕的确诊患者的研究，这些患者接受了飞梭式二氧化碳激光治疗，并使用温哥华疤痕量表（VSS）记录其进展情况。有 8 项研究纳入了系统回顾和荟萃分析。研究之间的治疗方案不同，患者的结果也不同。对 282 名患者的汇总数据显示，在接受飞梭式二氧化碳激光消融治疗后，VSS 的平均改善率为 29%。尽管研究之间治疗方案的异质性限制了本系统综述提供具体治疗建议的能力，但根据 VSS，烧伤疤痕经飞梭式二氧化碳激光治疗后整体呈改善趋势，这鼓励进一步探索该治疗模式作为一种治疗工具。
