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分次二氧化碳激光辅助药物递送在烧伤后瘢痕管理中的疗效——一项前瞻性研究。

Efficacy of fractional carbon dioxide laser-assisted drug delivery in the management of post-burn scars - A prospective study.

作者信息

Neema Shekhar, Vendhan Senkadhir, Vasudevan Biju, K Lekshmipriya, Dakshinamurthy Senkadhirdasan

机构信息

Department of Dermatology, Command Hospital, Lucknow, Uttar Pradesh, India.

Department of Dermatology, Dr. Babasaheb Ambedekar Memorial Hospital Central Railways Hospital, Mumbai, Maharashtra, India.

出版信息

J Cutan Aesthet Surg. 2024 Jul-Sep;17(3):219-226. doi: 10.25259/jcas_181_23. Epub 2024 Aug 29.

DOI:10.25259/jcas_181_23
PMID:39483650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11497552/
Abstract

OBJECTIVES

The objective of our study is to assess the efficacy of fractional carbon dioxide (CO2) laser-assisted drug delivery (LADD) in the management of post-burn scars.

MATERIAL AND METHODS

It is a prospective study conducted from March 2021 to February 2022, with 32 patients ranging in age from 9 to 52 years. The scars lasted anywhere from 6 months to 18 years. The ethical clearance of the Institutional Ethics Committee was obtained. The patient's median age was 22 (range, 09-52). Patients were assessed using a modified Vancouver scar scale (mVSS) score before and after receiving fractional CO2 laser at monthly intervals.

RESULTS

After one treatment, statistically significant improvements in pigment, thickness, and pliability were seen according to the mVSS scores, and these improvements persisted through the final laser session.

CONCLUSION

Our study has demonstrated that fractional CO2 LADD seems to be an encouraging approach in the management of post-burn scars with good patient satisfaction.

摘要

目的

我们研究的目的是评估分次二氧化碳（CO2）激光辅助药物递送（LADD）在烧伤后瘢痕管理中的疗效。

材料与方法

这是一项前瞻性研究，于2021年3月至2022年2月进行，纳入32例年龄在9至52岁之间的患者。瘢痕持续时间为6个月至18年。获得了机构伦理委员会的伦理批准。患者的中位年龄为22岁（范围为09 - 52岁）。在患者每月接受分次CO2激光治疗前后，使用改良温哥华瘢痕量表（mVSS）评分进行评估。

结果

根据mVSS评分，一次治疗后，色素、厚度和柔韧性方面有统计学意义的改善，且这些改善持续到最后一次激光治疗。

结论

我们的研究表明，分次CO2激光辅助药物递送似乎是一种令人鼓舞的烧伤后瘢痕管理方法，患者满意度良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/924d223adb1d/JCAS-17-219-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/67be69e364d2/JCAS-17-219-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/924d223adb1d/JCAS-17-219-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/3808835629ad/JCAS-17-219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/60bc4a3643a5/JCAS-17-219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/09d3b344de15/JCAS-17-219-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/21e231b3276e/JCAS-17-219-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/66b9ac99b9d5/JCAS-17-219-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/103c4e697d1b/JCAS-17-219-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/67be69e364d2/JCAS-17-219-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/ca9d90916c6b/JCAS-17-219-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/804620d8c83a/JCAS-17-219-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/8ff5d47dffb9/JCAS-17-219-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/340bff274169/JCAS-17-219-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5822/11497552/924d223adb1d/JCAS-17-219-g012.jpg

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