Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Lomonosov Moscow State University, School of Biology, Moscow, Russia.
Aging (Albany NY). 2020 Aug 15;12(15):15741-15755. doi: 10.18632/aging.103815.
The search for radioprotectors is an ambitious goal with many practical applications. Particularly, the improvement of human radioresistance for space is an important task, which comes into view with the recent successes in the space industry. Currently, all radioprotective drugs can be divided into two large groups differing in their effectiveness depending on the type of exposure. The first of these is radioprotectors, highly effective for pulsed, and some types of relatively short exposure to irradiation. The second group consists of long-acting radioprotectors. These drugs are effective for prolonged and fractionated irradiation. They also protect against impulse exposure to ionizing radiation, but to a lesser extent than short-acting radioprotectors. Creating a database on radioprotectors is a necessity dictated by the modern development of science and technology. We have created an open database, Radioprotectors.org, containing an up-to-date list of substances with proven radioprotective properties. All radioprotectors are annotated with relevant chemical and biological information, including transcriptomic data, and can be filtered according to their properties. Additionally, the performed transcriptomics analysis has revealed specific transcriptomic profiles of radioprotectors, which should facilitate the search for potent radioprotectors.
寻找辐射防护剂是一个具有许多实际应用的雄心勃勃的目标。特别是，随着太空工业的最近成功，提高人类对太空的辐射抗性是一项重要任务。目前，所有的辐射防护剂都可以分为两大类，根据暴露类型的不同，其效果也有所不同。其中之一是辐射防护剂，对脉冲辐射和某些类型的相对短时间的辐射暴露非常有效。第二类是长效辐射防护剂。这些药物对长时间和分次照射有效。它们还可以预防脉冲辐射的冲击，但效果不如短效辐射防护剂。创建一个辐射防护剂数据库是由现代科学技术发展所决定的必要条件。我们创建了一个开放的数据库，Radioprotectors.org，其中包含了具有经过验证的辐射防护特性的物质的最新清单。所有的辐射防护剂都用相关的化学和生物学信息进行了注释，包括转录组数据，并可以根据其特性进行过滤。此外，进行的转录组学分析揭示了辐射防护剂的特定转录组学特征，这应该有助于寻找有效的辐射防护剂。
