University Eye Hospital, Center for Ophthalmology, University of Tübingen, Tübingen, Germany.
Center for Rare Eye Diseases, University of Tübingen, Tübingen, Germany.
Ophthalmologica. 2021;244(5):396-407. doi: 10.1159/000510888. Epub 2020 Aug 17.
This work presents a quick clinical protocol for dark-adapted chromatic (DAC) perimetry as well as a novel clinical tool, scotopic chromatic pupil campimetry (CPC). The goal of the study was to explore the applicability of these methods in a clinical setting, their test-retest repeatability, and the congruence of the results. Local rod sensitivity was assessed at 36 locations within 30° eccentricity of the visual field in 15 healthy subjects (mean age 43 ± 16 years; 7 females and 8 males) with DAC perimetry (red and cyan stimuli) and CPC 2 times in repeated measurements. The duration of individual measurements was 370 ± 5 s for CPC and 366 ± 62 s for DAC perimetry. The intraclass correlation (ICC) coefficient was 0.53 for DAC perimetry cyan stimuli, 0.67 for red stimuli, and 0.93 for CPC. However, the spatial resolution of CPC was substantially smaller than in DAC perimetry. We did not find a correlation of DAC perimetry and CPC measurements on the global or the local level. In comparison to DAC perimetry, CPC shows a superior intervisit repeatability in detecting functional changes in the rod population in an objective way with lower spatial resolution. Our results also indicate that these 2 methods measure the rod function in different ways and could thus constitute complementary scotopic functional diagnostics.
本研究提出了一种快速的暗适应色觉（DAC）视野检查法及一种新颖的临床工具——暗适应色觉瞳孔 Campimetry（CPC）。研究目的是探索这些方法在临床环境中的适用性、测试-重测重复性以及结果的一致性。15 名健康受试者（平均年龄 43 ± 16 岁；女性 7 名，男性 8 名）在 30°视野偏心度内的 36 个位置接受了暗适应色觉（红、蓝刺激）和 CPC 2 次重复测量。单次测量的时间为 CPC 370 ± 5 s，DAC 视野检查 366 ± 62 s。CPC 的组内相关系数（ICC）为 0.53（蓝刺激）、0.67（红刺激），而 DAC 视野检查为 0.93。然而，CPC 的空间分辨率明显低于 DAC 视野检查。我们没有发现 DAC 视野检查和 CPC 测量在全局或局部水平上的相关性。与 DAC 视野检查相比，CPC 在以客观方式检测杆状细胞群体的功能变化方面具有更好的重测间重复性，但其空间分辨率较低。我们的研究结果还表明，这两种方法以不同的方式测量杆状功能，因此可以构成互补的暗适应功能诊断。
