College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
ACS Appl Mater Interfaces. 2020 Sep 9;12(36):40002-40012. doi: 10.1021/acsami.0c09469. Epub 2020 Aug 21.
Although immunotherapy has merged as an ideal cancer therapeutic strategy for preventing tumor growth and recurrence, effective approaches to treat immunologically cold tumors are still lacking. Herein, we reported a practical and extendable nanoplatform (HA/ZIF-8@ICG@IMQ) that facilely integrated various therapeutics and functions for boosting host antitumor immunity to treat immunologically cold tumors. The tumor-targeted and microenvironment-responsive HA/ZIF-8@ICG@IMQ facilitated the tumor-specific accumulation and release of photothermal agents and immune adjuvants. With near-infrared irradiation, the designed nanoparticles effectively enhanced the infiltration of cytotoxic T lymphocytes and helper T cells and effectively blocked the growth of primary and distant tumors. Moreover, the smart therapeutic could effectively prevent tumor rechallenge and recurrence with a long-term host immunological memory response. This method shows an effective immunologically cold tumor treatment using extendable nanotherapeutics and may have reference significance for clinical cancer therapy.
尽管免疫疗法已经成为预防肿瘤生长和复发的理想癌症治疗策略，但治疗免疫冷肿瘤的有效方法仍缺乏。在此，我们报道了一种实用且可扩展的纳米平台（HA/ZIF-8@ICG@IMQ），该平台可轻松整合各种治疗方法和功能，以增强宿主抗肿瘤免疫，从而治疗免疫冷肿瘤。肿瘤靶向和微环境响应的 HA/ZIF-8@ICG@IMQ 促进了光热剂和免疫佐剂的肿瘤特异性积累和释放。近红外辐射照射下，设计的纳米颗粒有效增强了细胞毒性 T 淋巴细胞和辅助性 T 细胞的浸润，并有效阻断了原发性和远处肿瘤的生长。此外，智能治疗可有效预防肿瘤再挑战和复发，并产生长期的宿主免疫记忆反应。该方法利用可扩展的纳米疗法有效治疗免疫冷肿瘤，对临床癌症治疗具有参考意义。
