Yang Youwen, Peng Shuping, Qi Fangwei, Zan Jun, Liu Guofeng, Zhao Zhenyu, Shuai Cijun
School of Intelligent Manufacturing and Equipment, Shenzhen Institute of Information Technology, Shenzhen 518172, China; Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China; Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
School of Basic Medical Science, Central South University, Changsha 410083, China; School of energy and machinery engineering, Jiangxi University of Science and Technology, Nanchang 330013, China.
Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111195. doi: 10.1016/j.msec.2020.111195. Epub 2020 Jun 13.
Biopolymer scaffold is expected to generate electrical stimulation, aiming to mimic an electrical microenvironment to promote cell growth. In this work, graphene and barium titanate (BT) was introduced into selective laser sintered poly-l-lactic acid (PLLA) scaffold. BT as one piezoelectric ceramic was used as the piezoelectric source, whereas graphene served as superior conductive filler. Significantly, the incorporated graphene enhanced the electrical conductivity and thereby increased the electric field strength applied on BT nanoparticles during poling. In this case, more electric domain within BT rearranged along the poling field direction, thus promoting the piezoelectric response of the composites. Results showed that the PLLA/BT/graphene scaffold exhibited relatively high output voltage of 1.4 V and current of 10 nA. Cells tests proved that these electrical signals considerably promoted cell proliferation and differentiation. Moreover, the scaffold exhibited improved mechanical properties due to the rigid particle enhancement effect and increased crystallinity.
生物聚合物支架有望产生电刺激，旨在模拟电微环境以促进细胞生长。在这项工作中，将石墨烯和钛酸钡（BT）引入选择性激光烧结的聚-L-乳酸（PLLA）支架中。BT作为一种压电陶瓷用作压电源，而石墨烯用作优良的导电填料。值得注意的是，掺入的石墨烯提高了电导率，从而增加了极化过程中施加在BT纳米颗粒上的电场强度。在这种情况下，BT内更多的电畴沿极化场方向重新排列，从而促进了复合材料的压电响应。结果表明，PLLA/BT/石墨烯支架表现出相对较高的1.4 V输出电压和10 nA电流。细胞测试证明，这些电信号显著促进了细胞增殖和分化。此外，由于刚性颗粒增强效应和结晶度增加，支架的机械性能得到改善。
