Donsì Francesco, Ferrari Giovanna
Department of Industrial Engineering, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
ProdAl Scarl, via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Foods. 2020 Aug 12;9(8):1100. doi: 10.3390/foods9081100.
In modern foods, the delivery systems for bioactive compounds play a fundamental role in health promotion, wellbeing, and disease prevention through diet. Nanotechnology has secured a fundamental role in the fabrication of delivery systems with the capability of modulating the in-product and in-body behavior for augmenting bioavailability and activity of bioactive compounds. Structured nanoemulsions and nanoparticles, liposomes, and niosomes can be designed to improve bioactives preservation after ingestion, mucoadhesion, as well as of their release and pathophysiological relevance. In the future, it is expected that the delivery systems will also contribute to augment the efficacy of the bioactive compounds, for example by improving the intestinal absorption and delivery in the bloodstream, as well as promoting the formation of additional bioactive metabolites by regulating the transformations taking place during digestion and the interaction with the intestinal microbiota.
在现代食品中，生物活性化合物的递送系统通过饮食在促进健康、提升幸福感和预防疾病方面发挥着重要作用。纳米技术在递送系统的制造中发挥了重要作用，这些递送系统能够调节产品内和体内行为，以提高生物活性化合物的生物利用度和活性。结构化纳米乳液、纳米颗粒、脂质体和非离子表面活性剂泡囊可被设计用于改善生物活性物质在摄入后的保存、粘膜粘附以及它们的释放和病理生理相关性。未来，预计递送系统还将有助于提高生物活性化合物的功效，例如通过改善肠道吸收和在血液中的递送，以及通过调节消化过程中发生的转化和与肠道微生物群的相互作用来促进额外生物活性代谢物的形成。
