Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Department of Food Technology, Faculty of Agriculture, University of Sultan Ageng Tirtayasa, Serang 42110, Indonesia.
Nutrients. 2020 Aug 12;12(8):2409. doi: 10.3390/nu12082409.
Fermented rice bran (FRB), a prospective supplement, has been proven to ameliorate certain medical conditions. However, its nutraceutical effect on muscle atrophy has never been investigated. The present study aimed to evaluate the effect of FRB on muscle atrophy in a streptozotocin (STZ)-induced diabetic rat model. Three groups of Sprague-Dawley rats, namely the control, STZ, and FRB groups, were treated as follows. The diabetic groups (STZ and FRB) were injected intraperitoneally with STZ (40 mg/kg BW), whereas the control group was injected with the vehicle. The STZ and control groups were fed the AIN93M diet, and the FRB group was fed 10% of FRB based on the AIN93M diet. The diabetic groups had reduced muscle size compared to the control group; however, these changes were alleviated in the FRB group. Moreover, the FRB group had a significantly lower expression of FBXO32/Atrogin-1 and TRIM63/MuRF1 ( < 0.05) due to blocked NF-κB activation. In conclusion, the anti-inflammatory effect of FRB may be beneficial for ameliorating muscle atrophy in diabetic conditions.
发酵米糠（FRB）作为一种有前景的补充剂，已被证明可改善某些医疗状况。然而，其在肌肉萎缩方面的营养效果尚未得到研究。本研究旨在评估 FRB 对链脲佐菌素（STZ）诱导的糖尿病大鼠模型中肌肉萎缩的影响。将三组 Sprague-Dawley 大鼠分为对照组、STZ 组和 FRB 组进行如下处理。糖尿病组（STZ 和 FRB）通过腹腔注射 STZ（40mg/kgBW），而对照组注射溶剂。对照组和 STZ 组给予AIN93M 饮食，FRB 组给予基于 AIN93M 饮食的 10% FRB。与对照组相比，糖尿病组的肌肉体积减小，但 FRB 组的这些变化得到缓解。此外，由于 NF-κB 激活被阻断，FRB 组的 FBXO32/Atrogin-1 和 TRIM63/MuRF1 的表达显著降低（<0.05）。总之，FRB 的抗炎作用可能有益于改善糖尿病条件下的肌肉萎缩。
