Laboratory for Leukocyte Signaling Research, Department of Pharmacology, Inha University School of Medicine, Incheon 22212, Korea.
Laboratory of Fundamental Research, Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon 34128, Korea.
Nutrients. 2020 Aug 12;12(8):2415. doi: 10.3390/nu12082415.
Postmenopausal osteoporosis is a common disorder resulting from increased osteoclastic activity. To determine the effect of on postmenopausal osteoporosis, ovariectomized (OVX) mice were treated with 500 mg/kg/day extract (Pg) alone or in combination with hot water extract of (Bo) daily for 10 weeks, and the effect of the treatments on OVX-induced bone loss was examined. Bone weight, bone mineral density (BMD), osteoclast (OC) formation, OC marker expression, and biochemical parameters in blood were determined. OVX significantly increased body weight and decreased bone weight compared with those in the Sham group ( < 0.01). Pg or Bo alone did not affect OVX-induced bone loss, but a combination of Pg and Bo (Pg:Bo) recovered bone weight. The bones of OVX mice showed lower BMD than that of Sham mice, and the Pg:Bo = 3:1 restored the decreased BMD. Single treatment with Pg or Bo did not alter OC formation; however, the Pg:Bo = 3:1 inhibited OC formation. In addition, Pg and Bo lowered the OVX-induced elevation in blood glucose level. Thus, we suggest that Pg in combination with proper materials, such as Bo, might be a potential candidate treatment with minimal side effects protect against postmenopausal osteoporosis.
绝经后骨质疏松症是一种常见的疾病，是由于破骨细胞活性增加所致。为了确定[药物名称]对绝经后骨质疏松症的影响，将去卵巢（OVX）小鼠用 500mg/kg/天[药物名称]提取物（Pg）单独或与[植物名称]热水提取物（Bo）联合治疗 10 周，并检查这些治疗对 OVX 诱导的骨丢失的影响。测定骨重、骨矿物质密度（BMD）、破骨细胞（OC）形成、OC 标志物表达和血液中的生化参数。与 Sham 组相比，OVX 显著增加了体重并降低了骨重（<0.01）。Pg 或 Bo 单独使用不会影响 OVX 诱导的骨丢失，但 Pg 和 Bo 的组合（Pg:Bo）恢复了骨重。OVX 小鼠的骨骼显示出比 Sham 小鼠更低的 BMD，而 Pg:Bo = 3:1 恢复了降低的 BMD。单一治疗 Pg 或 Bo 不会改变 OC 的形成；然而，Pg:Bo = 3:1 抑制了 OC 的形成。此外，Pg 和 Bo 降低了 OVX 引起的血糖水平升高。因此，我们认为 Pg 与适当的材料（如 Bo）联合使用可能是一种潜在的候选治疗方法，具有最小的副作用，可以预防绝经后骨质疏松症。
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