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动物病原体的细胞和细胞外蛋白质组,人畜共患病原体的近亲。 (注:原文中“Zoonotic and.”表述不完整,可能影响准确理解)

Cellular and Extracellular Proteome of the Animal Pathogen , a Close Relative of Zoonotic and .

作者信息

Möller Jens, Schorlemmer Svenja, Hofmann Jörg, Burkovski Andreas

机构信息

Microbiology Division, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Germany.

Biochemistry Division, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Germany.

出版信息

Proteomes. 2020 Aug 12;8(3):19. doi: 10.3390/proteomes8030019.

Abstract

is a newly described animal pathogen, closely related to the emerging human pathogen and , a major pathogen of small ruminants. In this study, proteins of a whole cell and a shaving fraction and the exoproteome of strain W25 were analyzed as a first proteome study of this species. In total, 1305 proteins were identified out of 2013 proteins encoded by the W25 genome sequence and number of putative virulence factors were detected already under standard growth conditions including phospholipase D and sialidase. An up to now uncharacterized trypsin-like protease is by far the most secreted protein in this species, indicating a putative role in pathogenicity. Furthermore, the proteome analyses carried out in this study support the recently published taxonomical delineation of from the closely related zoonotic species.

摘要

是一种新描述的动物病原体,与新兴的人类病原体以及小反刍动物的主要病原体密切相关。在本研究中,作为该物种的首次蛋白质组研究,分析了菌株W25的全细胞、刮取部分的蛋白质以及外蛋白质组。在由W25基因组序列编码的2013种蛋白质中,总共鉴定出1305种蛋白质,并且在包括磷脂酶D和唾液酸酶在内的标准生长条件下已经检测到了一些假定的毒力因子。到目前为止,一种未被表征的类胰蛋白酶是该物种中分泌最多的蛋白质,表明其在致病性中可能发挥作用。此外,本研究中进行的蛋白质组分析支持了最近发表的将该物种与密切相关的人畜共患病物种进行分类划分的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5cd/7564913/59caf7b1203f/proteomes-08-00019-g001.jpg

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