• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

动物病原新型棒状杆菌的系统基因组特征分析。

Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals.

机构信息

Professur für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.

出版信息

Antonie Van Leeuwenhoek. 2020 Aug;113(8):1225-1239. doi: 10.1007/s10482-020-01430-5. Epub 2020 Jun 4.

DOI:10.1007/s10482-020-01430-5
PMID:32500295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7334274/
Abstract

The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.

摘要

棒状杆菌属包括具有生物技术、医学和兽医重要性的物种。最近从一头野猪的坏死性淋巴结炎病例中分离出一株非典型的溃疡棒状杆菌 W25 菌株。在这项研究中，我们分析了该菌株的基因组序列，并将表型和毒力特性与其他棒状杆菌病原体进行了比较。系统发育基因组分析表明，W25 菌株与 PO100/5 和 KL1196 一起属于一个新种。后两种菌株分别从猪和狍子中分离出来；因此，该种似乎与动物有关。分离株 W25 可能是一种非产毒的毒力基因携带菌株，由于 spaBC 和 spaDEF 菌毛基因簇中基因功能的潜在丧失，其黏附咽和喉上皮细胞的能力可能受到损害。存在许多棒状杆菌毒力基因，包括编码磷脂酶 D 的 pld 基因。因此，该菌株可能能够在动物中引起严重的侵袭性感染，并在人类中引起人畜共患感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/2129027cb11c/10482_2020_1430_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/d8bdd801bd0d/10482_2020_1430_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/0c7549b0bf94/10482_2020_1430_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/d0bc92351d1f/10482_2020_1430_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/8653d37c490c/10482_2020_1430_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/99591bf5f765/10482_2020_1430_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/2129027cb11c/10482_2020_1430_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/d8bdd801bd0d/10482_2020_1430_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/0c7549b0bf94/10482_2020_1430_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/d0bc92351d1f/10482_2020_1430_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/8653d37c490c/10482_2020_1430_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/99591bf5f765/10482_2020_1430_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f60/7334274/2129027cb11c/10482_2020_1430_Fig6_HTML.jpg

相似文献

1
Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals.动物病原新型棒状杆菌的系统基因组特征分析。
Antonie Van Leeuwenhoek. 2020 Aug;113(8):1225-1239. doi: 10.1007/s10482-020-01430-5. Epub 2020 Jun 4.
2
Genome sequence of a pathogenic Corynebacterium ulcerans strain isolated from a wild boar with necrotizing lymphadenitis.从患有坏死性淋巴结炎的野猪分离出的致病性溃疡棒状杆菌菌株的基因组序列。
BMC Res Notes. 2019 Oct 25;12(1):692. doi: 10.1186/s13104-019-4704-3.
3
Non-toxigenic tox gene-bearing Corynebacterium ulcerans in a traumatic ulcer from a human case and his asymptomatic dog.来自一名人类病例及其无症状犬创伤性溃疡中的携带无毒力毒素基因的溃疡棒状杆菌。
Microbes Infect. 2015 Oct;17(10):717-9. doi: 10.1016/j.micinf.2015.07.004. Epub 2015 Aug 15.
4
Detection and virulence potential of a phospholipase D-negative Corynebacterium ulcerans from a concurrent diphtheria and infectious mononucleosis case.从一例并发白喉和传染性单核细胞增多症病例中分离出的磷脂酶D阴性溃疡棒状杆菌的检测及毒力潜力
Antonie Van Leeuwenhoek. 2019 Jul;112(7):1055-1065. doi: 10.1007/s10482-019-01240-4. Epub 2019 Feb 15.
5
sp. nov., a unique group of NTTB corynebacteria in wild boar and roe deer.新种，野猪和狍子中独特的 NTTB 棒状杆菌群。
Int J Syst Evol Microbiol. 2020 Jun;70(6):3614-3624. doi: 10.1099/ijsem.0.004195.
6
[Corynebacterium ulcerans infection in roe deer (Capreolus capreolus)].[狍（Capreolus capreolus）中的溃疡棒状杆菌感染]
Berl Munch Tierarztl Wochenschr. 2012 Mar-Apr;125(3-4):159-62.
7
Outbreak with clonally related isolates of Corynebacterium ulcerans in a group of water rats.一群水鼠中溃疡棒状杆菌克隆相关分离株的暴发。
BMC Microbiol. 2015 Feb 21;15:42. doi: 10.1186/s12866-015-0384-x.
8
NGS-based phylogeny of diphtheria-related pathogenicity factors in different Corynebacterium spp. implies species-specific virulence transmission.基于 NGS 的不同棒状杆菌属中白喉相关致病因子的系统发育表明了种特异性毒力传递。
BMC Microbiol. 2019 Feb 1;19(1):28. doi: 10.1186/s12866-019-1402-1.
9
Nontoxigenic tox-bearing Corynebacterium ulcerans infection among game animals, Germany.德国野生动物中的无毒产毒溃疡棒状杆菌感染
Emerg Infect Dis. 2014 Mar;20(3):448-52. doi: 10.3201/eid2003.130423.
10
Corynebacterium ulcerans in an immunocompromised patient with diphtheria and her dog.一名患有白喉的免疫功能低下患者及其犬身上的溃疡棒状杆菌
J Clin Microbiol. 2005 Feb;43(2):999-1001. doi: 10.1128/JCM.43.2.999-1001.2005.

引用本文的文献

1
First Report of Caseous Lymphadenitis by and Pulmonary Verminosis in a Roe Deer ( Linnaeus, 1758) in Italy.意大利一只狍（林奈，1758年）患干酪性淋巴结炎和肺寄生虫病的首例报告。
Animals (Basel). 2024 Feb 8;14(4):566. doi: 10.3390/ani14040566.
2
Proteomics of Toxigenic Corynebacteria.产毒棒状杆菌的蛋白质组学
Proteomes. 2023 Dec 30;12(1):2. doi: 10.3390/proteomes12010002.
3
Analysis of genomes from Portugal reveals a single cluster and a clade suggested to produce diphtheria toxin.对葡萄牙基因组的分析揭示了一个单一的集群和一个分支，这些分支被认为能产生白喉毒素。

本文引用的文献

1
Genome sequence of a pathogenic Corynebacterium ulcerans strain isolated from a wild boar with necrotizing lymphadenitis.从患有坏死性淋巴结炎的野猪分离出的致病性溃疡棒状杆菌菌株的基因组序列。
BMC Res Notes. 2019 Oct 25;12(1):692. doi: 10.1186/s13104-019-4704-3.
2
sp. nov., a rapidly growing scotochromogenic strain isolated from .新种，从 中分离得到的一株快速生长的 scotochromogenic 菌株。
Int J Syst Evol Microbiol. 2019 Nov;69(11):3465-3471. doi: 10.1099/ijsem.0.003644.
3
Beyond diphtheria toxin: cytotoxic proteins of Corynebacterium ulcerans and Corynebacterium diphtheriae.
PeerJ. 2023 Mar 9;11:e14895. doi: 10.7717/peerj.14895. eCollection 2023.
4
Multi-Omics of 12CS0282 and an In Silico Reverse Vaccinology Approach Reveal Novel Vaccine and Drug Targets.12CS0282的多组学研究及计算机辅助反向疫苗学方法揭示新型疫苗和药物靶点
Proteomes. 2022 Nov 23;10(4):39. doi: 10.3390/proteomes10040039.
5
New Species with the Potential to Produce Diphtheria Toxin.具有产生白喉毒素潜力的新物种。
Pathogens. 2022 Oct 30;11(11):1264. doi: 10.3390/pathogens11111264.
6
Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the Genus .脂肪酸生物合成、分枝菌酸生物合成及该属成员间临床相关性的系统基因组学重新评估
Front Microbiol. 2021 Dec 23;12:802532. doi: 10.3389/fmicb.2021.802532. eCollection 2021.
7
Newly Isolated Animal Pathogen Is Cytotoxic to Human Epithelial Cells.新分离的动物病原体对人上皮细胞具有细胞毒性。
Int J Mol Sci. 2021 Mar 29;22(7):3549. doi: 10.3390/ijms22073549.
8
Taxonomic classification of strain PO100/5 shows a broader geographic distribution and genetic markers of the recently described Corynebacterium silvaticum.PO100/5 菌株的分类学分类显示了更广泛的地理分布和最近描述的森林棒状杆菌的遗传标记。
PLoS One. 2020 Dec 21;15(12):e0244210. doi: 10.1371/journal.pone.0244210. eCollection 2020.
9
Cellular and Extracellular Proteome of the Animal Pathogen , a Close Relative of Zoonotic and .动物病原体的细胞和细胞外蛋白质组，人畜共患病原体的近亲。 （注：原文中“Zoonotic and.”表述不完整，可能影响准确理解）
Proteomes. 2020 Aug 12;8(3):19. doi: 10.3390/proteomes8030019.
除白喉毒素外：溃疡棒状杆菌和白喉棒状杆菌的细胞毒素蛋白。
Microbiology (Reading). 2019 Aug;165(8):876-890. doi: 10.1099/mic.0.000820. Epub 2019 Jun 4.
4
TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy.TYGS 是一个自动化的高通量平台，用于最先进的基于基因组的分类学。
Nat Commun. 2019 May 16;10(1):2182. doi: 10.1038/s41467-019-10210-3.
5
Proteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae.白喉类毒素疫苗的蛋白质组学研究揭示了多种具有免疫原性的蛋白质，这些蛋白质可能有助于保护人类免受白喉棒状杆菌的侵害。
Vaccine. 2019 May 21;37(23):3061-3070. doi: 10.1016/j.vaccine.2019.04.059. Epub 2019 Apr 26.
6
High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries.高通量 ANI 分析 9 万余组原核基因组揭示了清晰的物种界限。
Nat Commun. 2018 Nov 30;9(1):5114. doi: 10.1038/s41467-018-07641-9.
7
Revisiting the Taxonomic Status of the Biomedically and Industrially Important Genus , Using a Phylogenomic Approach.利用系统基因组学方法重新审视具有生物医学和工业重要性的属的分类地位。
Front Microbiol. 2018 Sep 27;9:2281. doi: 10.3389/fmicb.2018.02281. eCollection 2018.
8
Frankia irregularis sp. nov., an actinobacterium unable to nodulate its original host, Casuarina equisetifolia, but effectively nodulates members of the actinorhizal Rhamnales.不规则弗兰克氏菌（Frankia irregularis），一种无法结瘤其原始宿主木麻黄（Casuarina equisetifolia）的放线菌，但能有效结瘤真核根瘤菌目（actinorhizal Rhamnales）的成员。
Int J Syst Evol Microbiol. 2018 Sep;68(9):2883-2914. doi: 10.1099/ijsem.0.002914. Epub 2018 Jul 16.
9
Genomic analyses reveal two distinct lineages of strains.基因组分析揭示了菌株的两个不同谱系。
New Microbes New Infect. 2018 May 25;25:7-13. doi: 10.1016/j.nmni.2018.05.005. eCollection 2018 Sep.
10
PathoBacTyper: A Web Server for Pathogenic Bacteria Identification and Molecular Genotyping.PathoBacTyper：用于病原菌鉴定和分子基因分型的网络服务器。
Front Microbiol. 2017 Aug 3;8:1474. doi: 10.3389/fmicb.2017.01474. eCollection 2017.