Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, USA.
Department of Biology, Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, USA.
J Biomater Sci Polym Ed. 2020 Dec;31(18):2362-2380. doi: 10.1080/09205063.2020.1812039. Epub 2020 Sep 3.
An antibacterial dental light-cured glass-ionomer cement has been developed and evaluated. An antibacterial furanone derivative was synthesized and covalently attached onto the surface of alumina filler particles. The formed antibacterial fillers were then mixed into a light-curable glass-ionomer cement formulation. Surface hardness and bacterial viability were used to evaluate the modified cements. Effects of coated furanone moiety content on the modified fillers, modified alumina filler particle size and loading, and total glass filler content were investigated. Results showed that increasing antibacterial furanone content, modified particle size and loading, and total glass filler content generally increased surface hardness. Increasing furanone moiety, filler loading and total filler content increased antibacterial activity. On the other hand, increasing particle size decreased antibacterial activity. The leaching tests indicate that the modified experimental cement showed no leachable antibacterial component to bacteria and cells.
一种抗菌牙科光固化玻璃离子水门汀已经开发和评估。合成了一种抗菌呋喃酮衍生物，并将其共价键合到氧化铝填料颗粒的表面。然后将形成的抗菌填料混合到光固化玻璃离子水门汀配方中。使用表面硬度和细菌活力来评估改性水泥。研究了涂覆的呋喃酮部分含量、改性氧化铝填料粒径和负载量以及总玻璃填料含量对改性填料的影响。结果表明，随着抗菌呋喃酮含量、改性颗粒粒径和负载量以及总玻璃填料含量的增加，表面硬度通常会增加。增加呋喃酮部分含量、填料负载量和总填料含量会增加抗菌活性。另一方面，颗粒粒径的增加会降低抗菌活性。浸出试验表明，改性实验水泥对细菌和细胞没有可浸出的抗菌成分。
