Chen Yong, Caneli Gulsah, Almousa Rashed, Hill Kayla, Na Sungsoo, Anderson Gregory G, Xie Dong
Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana.
Department of Materials Science, Jinchu University, Hubei, China.
Polym Adv Technol. 2020 Dec;31(12):3048-3058. doi: 10.1002/pat.5029. Epub 2020 Aug 13.
A novel antimicrobial dental self-cured glass-ionomer cement has been developed and evaluated. Alumina filler particles were covalently coated with an antibacterial polymer and blended into a self-cured glass-ionomer cement formulation. Surface hardness and bacterial viability were used to evaluate the modified cements. Results showed that the modified cements exhibited a significantly enhanced antibacterial activity along with improved surface hardness. Effects of antibacterial moiety content, alumina particle size and loading, and total filler content were investigated. It was found that increasing antibacterial moiety content, particle size and loading, and total filler content generally increased surface hardness. Increasing antibacterial moiety, filler loading and total filler content increased antibacterial activity. On the other hand, increasing particle size showed a negative impact on antibacterial activity. The leaching tests indicate no cytotoxicity produced from the modified cements to both bacteria and 3T3 mouse fibroblast cells.
一种新型抗菌牙科自固化玻璃离子水门汀已被研发并评估。氧化铝填料颗粒用抗菌聚合物进行共价包覆，并混入自固化玻璃离子水门汀配方中。通过表面硬度和细菌活力来评估改性水门汀。结果表明，改性水门汀展现出显著增强的抗菌活性以及改善的表面硬度。研究了抗菌部分含量、氧化铝粒径和负载量以及总填料含量的影响。发现增加抗菌部分含量、粒径和负载量以及总填料含量通常会提高表面硬度。增加抗菌部分、填料负载量和总填料含量会提高抗菌活性。另一方面，增大粒径对抗菌活性有负面影响。浸出试验表明改性水门汀对细菌和3T3小鼠成纤维细胞均无细胞毒性。
