School of Chemical Engineering, Jeonbuk National University (formerly Chonbuk National University), Baekje-daero, Jeonju-si, Jeollabuk-do, 54896, Republic of Korea.
Faculty of Biotechnology, Ho Chi Minh City University of Food Industry, Ho Chi Minh City, Vietnam.
Sci Rep. 2020 Aug 17;10(1):13905. doi: 10.1038/s41598-020-70900-7.
The present study proposes a simple yet effective method of cellulose coating onto chitosan (CS) hydrogel beads and application thereof as drug carriers. The beads were coated with cellulose dissolved in 1-ethyl-3-methylimidazolium acetate, an ionic liquid (IL) via a one-pot one-step process. Water molecules present in the CS beads diffused outward upon contact with the cellulose-IL mixture and acted as an anti-solvent. This allowed the surface of the beads to be coated with the regenerated cellulose. The regenerated cellulose was characterized by FE-SEM, FT-IR, and XRD analyses. To test potential application of the cellulose-coated CS hydrogel beads as a drug carrier, verapamil hydrochloride (VRP), used as a model drug, was impregnated into the beads. When the VRP-impregnated beads were immersed in the simulated gastric fluid (pH 1.2), the VRP was released in an almost ideal linear pattern. This easily fabricated cellulose-coated CS beads showed the possibility for application as carriers for drug release control.
本研究提出了一种简单而有效的将纤维素涂覆到壳聚糖（CS）水凝胶珠上的方法，并将其应用于药物载体。通过一锅一步法，将溶解在 1-乙基-3-甲基咪唑醋酸盐（一种离子液体（IL））中的纤维素涂覆到 CS 水凝胶珠上。CS 珠中的水分子与纤维素-IL 混合物接触时向外扩散，起到反溶剂的作用。这使得珠的表面可以被再生纤维素覆盖。再生纤维素通过 FE-SEM、FT-IR 和 XRD 分析进行了表征。为了测试纤维素涂覆的 CS 水凝胶珠作为药物载体的潜在应用，将盐酸维拉帕米（VRP）作为模型药物浸渍到珠中。当将 VRP 浸渍的珠浸入模拟胃液（pH 1.2）中时，VRP 以近乎理想的线性模式释放。这种易于制备的纤维素涂覆的 CS 珠显示出作为药物释放控制载体的应用可能性。
