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钙离子对气道平滑肌细胞收缩与舒张机制的研究进展。

Research progress in the mechanism of calcium ion on contraction and relaxation of airway smooth muscle cells.

机构信息

Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

J Recept Signal Transduct Res. 2021 Apr;41(2):117-122. doi: 10.1080/10799893.2020.1806315. Epub 2020 Aug 18.

DOI:10.1080/10799893.2020.1806315
PMID:32808844
Abstract

lntracellular calcium ion is the key secondary messenger system of the cellular processes in airway smooth muscle cells(ASMc). The treatment and regulation of Ca in airway smooth muscle (ASM) is, in part, to associated with many airway diseases such as asthma, COPD and pulmonary fibrosis. The mechanism of contraction and relaxation of ASM is a concerned aspect in airway diseases. This review emphasizes established and recent discoveries whice show the research progress of Ca on cell contraction and relaxation in ASM in recent years, to provide theoretical support and new targets for clinical prevention and treatment of perioperative bronchospasm and variousrespiratory related diseases.

摘要

细胞内钙离子是气道平滑肌细胞（ASMC）细胞过程的关键二级信使系统。气道平滑肌（ASM）中钙的治疗和调节部分与许多气道疾病有关，如哮喘、COPD 和肺纤维化。ASM 的收缩和松弛机制是气道疾病关注的一个方面。本综述强调了已建立的和最近的发现，这些发现展示了近年来细胞内钙对 ASM 细胞收缩和松弛的研究进展，为围手术期支气管痉挛和各种呼吸相关疾病的临床预防和治疗提供理论支持和新靶点。

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