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本体感受回路中神经元多样性和突触特异性的内在控制。

Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit.

机构信息

Neuroscience Institute, Department of Neuroscience and Physiology, NYU School of Medicine, New York, United States.

Department of Neurobiology, University of Chicago, Chicago, United States.

出版信息

Elife. 2020 Aug 18;9:e56374. doi: 10.7554/eLife.56374.

DOI:10.7554/eLife.56374
PMID:32808924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7467731/
Abstract

Relay of muscle-derived sensory information to the CNS is essential for the execution of motor behavior, but how proprioceptive sensory neurons (pSNs) establish functionally appropriate connections is poorly understood. A prevailing model of sensory-motor circuit assembly is that peripheral, target-derived, cues instruct pSN identities and patterns of intraspinal connectivity. To date no known intrinsic determinants of muscle-specific pSN fates have been described in vertebrates. We show that expression of Hox transcription factors defines pSN subtypes, and these profiles are established independently of limb muscle. The gene is expressed by pSNs and motor neurons (MNs) targeting distal forelimb muscles, and sensory-specific depletion of in mice disrupts sensory-motor synaptic matching, without affecting pSN survival or muscle targeting. These results indicate that the diversity and central specificity of pSNs and MNs are regulated by a common set of determinants, thus linking early rostrocaudal patterning to the assembly of limb control circuits.

摘要

肌肉源性感觉信息向中枢神经系统的传递对于执行运动行为至关重要，但本体感觉神经元 (pSN) 如何建立功能适当的连接尚不清楚。感觉运动回路组装的一个流行模型是，外周、靶源性线索指示 pSN 的身份和脊髓内连接模式。迄今为止，在脊椎动物中尚未描述已知的内在决定肌肉特异性 pSN 命运的因素。我们表明，Hox 转录因子的表达定义了 pSN 亚型，并且这些特征的建立独立于肢体肌肉。基因在靶向远侧前肢肌肉的 pSN 和运动神经元 (MN) 中表达，并且在小鼠中特异性地耗尽会破坏感觉运动突触匹配，而不会影响 pSN 存活或肌肉靶向。这些结果表明，pSN 和 MN 的多样性和中枢特异性受一组共同决定因素的调节，从而将早期头尾部模式与肢体控制回路的组装联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/e732681f51cd/elife-56374-fig7-figsupp1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/b2d0be7ecd60/elife-56374-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/e732681f51cd/elife-56374-fig7-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/513842b57384/elife-56374-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/496473a22061/elife-56374-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/f978bccac178/elife-56374-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/ac25afce38ab/elife-56374-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/deaeadea9f31/elife-56374-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/5297ab345352/elife-56374-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/2762ce21c83c/elife-56374-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/ebed5ae8ad90/elife-56374-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/b34ad83b4bcb/elife-56374-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/dd75bb48b3d9/elife-56374-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/3f0135e6c25c/elife-56374-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/7614295641c4/elife-56374-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/b2d0be7ecd60/elife-56374-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/7467731/e732681f51cd/elife-56374-fig7-figsupp1.jpg

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