Moreno-Eutimio Mario Adán, Martínez-Alemán Carmen Estefanía, Aranda-Uribe Ivan Sammir, Aquino-Jarquin Guillermo, Cabello-Gutierrez Carlos, Fragoso José Manuel, Barbosa-Cobos Rosa Elda, Saavedra Miguel A, Ramírez-Bello Julian
Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.
Unidad de Investigación, Hospital Juárez de México, Mexico City, Mexico.
Clin Rheumatol. 2021 Mar;40(3):929-939. doi: 10.1007/s10067-020-05332-9. Epub 2020 Aug 18.
The aim of this study was to examine the association of three TNFSF4 single nucleotide variants (SNVs) with systemic lupus erythematosus (SLE) susceptibility in Mexican patients.
Genotypes of the TNFSF4 rs1234315T/C, rs2205960G/T, and rs704840T/G SNVs were determined using a TaqMan assay. In our study, we included 395 patients with SLE and 500 controls.
Our information shows a significant difference in the allelic and genotypic frequency of the three TNFSF4 SNVs between cases and controls. Thus, our data showed an association between TNFSF4 rs1234315T/C (T vs. C, OR 1.40, p = 0.00087), rs2205960G/T (G vs. T, OR 1.32, p = 0.0037), and rs704840T/G (T vs. G, OR 1.41, p = 0.0003) and SLE susceptibility in Mexican subjects. Besides, we conducted a meta-analysis to determine the role of TNFSF4 rs2205960G/T and SLE susceptibility; our results showed that this variant is a risk factor for SLE in Latin Americans and Asians.
Our results show that TNFSF4 rs1234315T/C, rs2205960G/T, and rs704840T/G are risk factors to SLE in Mexicans. This is the first study to document an association between TNFSF4 rs704840T/G and SLE in a Latin American population. In addition, our meta-analysis showed that TNFSF4 rs2205960G/T is a risk factor for Asians and Latin Americans. Key Point • The TNFSF4 rs1234315T/C, rs2205960G/T, and rs704849T/G SNVs are risk factors to SLE in patients from Mexico.
本研究旨在探讨三个肿瘤坏死因子超家族成员4（TNFSF4）单核苷酸变异（SNV）与墨西哥患者系统性红斑狼疮（SLE）易感性之间的关联。
采用TaqMan分析方法确定TNFSF4 rs1234315T/C、rs2205960G/T和rs704840T/G SNV的基因型。本研究纳入了395例SLE患者和500例对照。
我们的信息显示，病例组和对照组之间三个TNFSF4 SNV的等位基因频率和基因型频率存在显著差异。因此，我们的数据显示TNFSF4 rs1234315T/C（T对C，比值比[OR]1.40，p = 0.00087）、rs2205960G/T（G对T，OR 1.32，p = 0.0037）和rs704840T/G（T对G，OR 1.41，p = 0.0003）与墨西哥人群的SLE易感性之间存在关联。此外，我们进行了一项荟萃分析以确定TNFSF4 rs2205960G/T与SLE易感性的关系；我们的结果表明，该变异是拉丁美洲人和亚洲人患SLE的一个危险因素。
我们的结果表明，TNFSF4 rs1234315T/C、rs2205960G/T和rs704840T/G是墨西哥人患SLE的危险因素。这是第一项记录TNFSF4 rs704840T/G与拉丁美洲人群SLE之间关联的研究。此外，我们的荟萃分析表明，TNFSF4 rs2205960G/T是亚洲人和拉丁美洲人的一个危险因素。关键点•TNFSF4 rs1234315T/C、rs2205960G/T和rs704849T/G SNV是墨西哥患者患SLE的危险因素。
