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Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes.

作者信息

Fields S, Chaleff D T, Sprague G F

机构信息

Department of Microbiology, State University of New York, Stony Brook 11794.

出版信息

Mol Cell Biol. 1988 Feb;8(2):551-6. doi: 10.1128/mcb.8.2.551-556.1988.

DOI:10.1128/mcb.8.2.551-556.1988
PMID:3280969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363179/
Abstract

Cell type specialization in yeast haploids involves the mutually exclusive expression of one of two sets of genes, the a-specific and alpha-specific genes. We demonstrated that the products of the STE7, STE11, and STE12 genes were required for the expression of both gene sets. RNA levels transcribed from these gene sets were significantly decreased but not abolished in haploids containing a null mutation in the STE7, STE11, or STE12 gene. Transcript levels from the a- and alpha-specific gene sets were not further reduced in strains harboring mutations in all three STE genes, suggesting that STE7, STE11, and STE12 are required for the same aspect of transcription. We further showed that the requirement for these products was not the same for each member of a particular gene set. However, for any given a- or alpha-specific gene, the effect on RNA levels of any of the three ste mutations was similar.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/8a7c6c946a67/molcellb00062-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/aa27d2ae7226/molcellb00062-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/ccdd3cdfe380/molcellb00062-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/05a35ef82ab1/molcellb00062-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/8a7c6c946a67/molcellb00062-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/aa27d2ae7226/molcellb00062-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/ccdd3cdfe380/molcellb00062-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/05a35ef82ab1/molcellb00062-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f0/363179/8a7c6c946a67/molcellb00062-0050-b.jpg

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1
Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes.
Mol Cell Biol. 1988 Feb;8(2):551-6. doi: 10.1128/mcb.8.2.551-556.1988.
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本文引用的文献

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EMBO J. 1985 Oct;4(10):2643-8. doi: 10.1002/j.1460-2075.1985.tb03982.x.
2
Transcriptional control in the production of liver-specific mRNAs.肝脏特异性mRNA产生过程中的转录调控。
Cell. 1981 Mar;23(3):731-9. doi: 10.1016/0092-8674(81)90436-0.
3
Control of cell type in yeast by the mating type locus. The alpha 1-alpha 2 hypothesis.酵母中交配型基因座对细胞类型的控制。α1-α2假说。
V 类肌球蛋白 Myo2p 在酵母交配反应期间对 Fus2p 运输和肌动蛋白极化是必需的。
Mol Biol Cell. 2009 Jun;20(12):2909-19. doi: 10.1091/mbc.e08-09-0923. Epub 2009 Apr 29.
4
Interspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts.种间差异揭示了酿酒酵母中α特异性基因的保守阻遏物。
Genes Dev. 2008 Jun 15;22(12):1704-16. doi: 10.1101/gad.1640008.
5
Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.Cdc37在蛋白激酶质量控制中具有不同作用，可保护新生肽链不被降解并促进翻译后成熟。
J Cell Biol. 2007 Jan 29;176(3):319-28. doi: 10.1083/jcb.200604106. Epub 2007 Jan 22.
6
Transcription factor STE12alpha has distinct roles in morphogenesis, virulence, and ecological fitness of the primary pathogenic yeast Cryptococcus gattii.转录因子STE12α在主要致病性酵母加氏隐球菌的形态发生、毒力和生态适应性方面具有不同作用。
Eukaryot Cell. 2006 Jul;5(7):1065-80. doi: 10.1128/EC.00009-06.
7
Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.全基因组表达分析揭示的HOG MAPK信号通路组分的独特和冗余作用
Mol Biol Cell. 2004 Feb;15(2):532-42. doi: 10.1091/mbc.e03-07-0521. Epub 2003 Oct 31.
8
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Feedback phosphorylation of the yeast a-factor receptor requires activation of the downstream signaling pathway from G protein through mitogen-activated protein kinase.酵母a因子受体的反馈磷酸化需要激活从G蛋白到丝裂原活化蛋白激酶的下游信号通路。
Mol Cell Biol. 2000 Jan;20(2):563-74. doi: 10.1128/MCB.20.2.563-574.2000.
10
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.新型隐球菌的交配和单倍体产孢需要G蛋白β亚基GPB1。
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4
Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.对多肽交配激素的细胞分裂控制无反应的酿酒酵母突变体。
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5
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6
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8
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Mol Cell Biol. 1983 Aug;3(8):1440-50. doi: 10.1128/mcb.3.8.1440-1450.1983.
10
Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae.细胞外抑制作用使得酿酒酵母的信息素缺陷型不育突变体能够进行交配。
J Bacteriol. 1983 Aug;155(2):903-6. doi: 10.1128/jb.155.2.903-906.1983.