纳洛酮对哌替啶所致新生儿抑制的影响。第一部分——静脉注射纳洛酮。
Effects of naloxone on pethidine-induced neonatal depression. Part I--Intravenous naloxone.
作者信息
Wiener P C, Hogg M I, Rosen M
出版信息
Br Med J. 1977 Jul 23;2(6081):228-9. doi: 10.1136/bmj.2.6081.228.
Abstract
Infants whose mothers had had pethidine during labour were given either naloxone 40 microgram or isotonic saline administered intravenously double-blind within one minute of birth. Peak alveolar carbon dioxide tension, carbon dioxide excretion, alveolar ventilation, feeding behaviour, and habituation to a specific sound stimulus were measured regularly up to 48 hours after birth. Alveolar carbon dioxide tension was significantly lower and alveolar ventilation significantly higher half an hour after birth in the naloxone-treated group than in the saline-treated group, but these differences between the groups were not significant at any other time, and there were no significant differences in sucking frequency or pressure, milk consumption, or habituation to the auditory stimulus.
摘要
母亲在分娩期间使用过哌替啶的婴儿，在出生后1分钟内通过双盲法静脉注射40微克纳洛酮或等渗盐水。在出生后48小时内定期测量峰值肺泡二氧化碳张力、二氧化碳排出量、肺泡通气量、喂养行为以及对特定声音刺激的习惯化。与生理盐水治疗组相比，纳洛酮治疗组在出生后半小时时的肺泡二氧化碳张力显著降低，肺泡通气量显著升高，但两组之间在其他任何时间的差异均无统计学意义，并且在吸吮频率或压力、奶量摄入或对听觉刺激的习惯化方面也没有显著差异。
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本文引用的文献
1
EFFECTS OF MEPERIDINE ON THE NEWBORN INFANT.
Am J Obstet Gynecol. 1964 Aug 15;89:1009-15. doi: 10.1016/0002-9378(64)90292-3.
2
Serial oxygen saturation studies of newborn infants following obstetrical complications, difficult deliveries, and cesarean section.对患有产科并发症、难产及剖宫产的新生儿进行连续血氧饱和度研究。
Am J Obstet Gynecol. 1957 May;73(5):1011-9; discussion, 1019-21. doi: 10.1016/s0002-9378(16)37172-1.
3
Newborn sucking behavior affected by obstetric sedation.新生儿吸吮行为受产科镇静影响。
Pediatrics. 1966 Jun;37(6):1012-6.
4
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7
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8
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