Zlatarova Zornitsa Ivanova, Dokova Klara Georgieva
Department of Ophthalmology and Visual Science, Medical University, Varna, Bulgaria.
Department of Social Medicine and Health Care Organization, Medical University, Varna, Bulgaria.
Ophthalmic Epidemiol. 2021 Jun;28(3):198-204. doi: 10.1080/09286586.2020.1808230. Epub 2020 Aug 18.
Malignant eyelid tumours are the most common malignancies in ophthalmic practice. We report here the incidence of non-melanoma eyelid malignancies in Bulgaria, for the period 2000-2015.
All cases coded with the International Classification of Diseases (ICD) code C 44.1, received from the Bulgarian National Cancer Registry, were used for estimating crude incidence rates by age and sex. In addition, directly age standardized incidence rates for non-melanoma eyelid malignancies are presented based on the European Standard population (year 2013) for Bulgaria and the region of Varna.
Over the 16-year period there were 3,046 cases in total, of which 1,457 (47.8%) were among men. The age standardized rate (ASR) of non-melanoma eyelid malignancies in men was 2.9 per 100,000 (95% CI 2.79-3.11), in women it was 2.4 per 100,000 (95% CI 2.30-2.54), and the mean ASR was 2.6 per 100,000 (95% CI 2.53-2.73) for both sexes during the period. The ASR increased for women and for both sexes combined.The risk of eyelid malignancies was higher for men than for women with RR of 1.21 (95% CI 1.08-1.41) during the whole period. The risk was higher in women up to the age of 55 and over 55 years it was higher in men.
We report results for the incidence of eyelid non-melanoma malignancies in a south-eastern European country, Bulgaria. They are comparable with earlier reports from other European countries.
恶性眼睑肿瘤是眼科临床最常见的恶性肿瘤。在此，我们报告2000 - 2015年期间保加利亚非黑色素瘤眼睑恶性肿瘤的发病率。
从保加利亚国家癌症登记处获取的所有国际疾病分类（ICD）编码为C 44.1的病例，用于按年龄和性别估算粗发病率。此外，还根据保加利亚和瓦尔纳地区的欧洲标准人口（2013年）给出了非黑色素瘤眼睑恶性肿瘤的直接年龄标准化发病率。
在这16年期间，共有3046例病例，其中1457例（47.8%）为男性。男性非黑色素瘤眼睑恶性肿瘤的年龄标准化率（ASR）为每10万人2.9例（95%可信区间2.79 - 3.11），女性为每10万人2.4例（95%可信区间2.30 - 2.54），在此期间两性的平均ASR为每10万人2.6例（95%可信区间2.53 - 2.73）。女性以及两性合计的ASR均有所上升。在整个期间，男性患眼睑恶性肿瘤的风险高于女性，相对危险度（RR）为1.21（95%可信区间1.08 - 1.41）。55岁及以下女性的风险较高，55岁以上男性的风险较高。
我们报告了东南欧国家保加利亚眼睑非黑色素瘤恶性肿瘤的发病率结果。这些结果与其他欧洲国家早期的报告具有可比性。
