Lin Hsin-Yi, Cheng Ching-Yu, Hsu Wen-Ming, Kao W H Linda, Chou Pesus
Department of Ophthalmology, School of Medicine, National Yang Ming University, Taipei, Taiwan.
Ophthalmology. 2006 Nov;113(11):2101-7. doi: 10.1016/j.ophtha.2006.06.001. Epub 2006 Sep 7.
To describe the epidemiologic characteristics and incidence trends of primary eyelid cancers in the Chinese population in Taiwan between 1979 and 1999.
Retrospective population-based cancer registry data review.
A total of 1166 primary eyelid cancers coded to International Classification of Diseases 8 or 9, site 172.1 (malignant melanoma of eyelid) and 173.1 (other malignant neoplasm of eyelid) were retrieved from the Taiwan National Cancer Registry between January 1979 and December 1999. Of these, 1121 (96.1%) were histopathologically verified and were used for analysis.
Age- and gender-specific incidence rates were calculated and were age-adjusted to the 2000 world standard population. Trends in incidence rates were estimated by calculating the annual percentage change. We further examined the effects of age, period of diagnosis, and birth cohort on incidence trends using age-period-cohort analysis.
Age-standardized incidence rate.
The mean age at diagnosis of eyelid cancers was 62.6+/-14.1 years. The average annual age-standardized incidence rate was 3.2 per million during the study period. There was an overall increase of incidence rates from 1.5 per million in 1979 to 5.1 per million in 1999, with an annual percentage change of 4.63% (P<0.001). The most common eyelid malignancy was basal cell carcinoma (BCC; 65.1%), followed by squamous cell carcinoma (12.6%), and sebaceous cell carcinoma (7.9%). The increasing rates were mainly driven by an increase in the incidence of BCC. Cohort effects were found to play a major role in terms of model fit for the incidence trends of BCC.
These national data reveal a rapidly increasing incidence of eyelid cancers from 1979 to 1999 in Taiwan. Basal cell carcinoma dominates the incidence trends, and the significant cohort effects give a warning of increasing risk of BCC in younger birth cohorts.
描述1979年至1999年间台湾地区中国人群原发性眼睑癌的流行病学特征及发病率趋势。
基于人群的回顾性癌症登记数据回顾。
1979年1月至1999年12月期间，从台湾地区癌症登记处检索出1166例原发性眼睑癌病例，其疾病编码依据国际疾病分类第8版或第9版，部位编码为172.1（眼睑恶性黑色素瘤）和173.1（眼睑其他恶性肿瘤）。其中，1121例（96.1%）经组织病理学证实，用于分析。
计算年龄和性别特异性发病率，并根据2000年世界标准人口进行年龄调整。通过计算年度百分比变化来估计发病率趋势。我们还使用年龄-时期-队列分析进一步研究年龄、诊断时期和出生队列对发病率趋势的影响。
年龄标准化发病率。
眼睑癌诊断时的平均年龄为62.6±14.1岁。研究期间平均年度年龄标准化发病率为每百万3.2例。发病率总体呈上升趋势，从1979年的每百万1.5例增至1999年的每百万5.1例，年度百分比变化为4.63%（P<0.001）。最常见的眼睑恶性肿瘤是基底细胞癌（BCC；65.1%），其次是鳞状细胞癌（12.6%）和皮脂腺癌（7.9%）。发病率上升主要由基底细胞癌发病率增加所致。队列效应在基底细胞癌发病率趋势的模型拟合方面起主要作用。
这些全国性数据显示，1979年至1999年间台湾地区眼睑癌发病率迅速上升。基底细胞癌在发病率趋势中占主导地位，显著的队列效应警示年轻出生队列中基底细胞癌风险增加。
