Research Center for Molecular Exercise Science, University of Physical Education, Alkotas str. 44, Budapest, 1123, Hungary.
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, 113-8654, Japan.
Biogerontology. 2020 Dec;21(6):807-815. doi: 10.1007/s10522-020-09895-7. Epub 2020 Aug 18.
It has been demonstrated that physical exercise and probiotic supplementation delay the progress of Alzheimer's Disease (AD) in male APP/PS1 mice. However, it has also been suggested that both exercise and AD have systemic effects. We have studied the effects of exercise training and probiotic treatment on microbiome and biochemical signalling proteins in the liver. The results suggest that liver is under oxidative stress, since SOD2 levels of APP/PS1 mice were decreased when compared to a wild type of mice. Exercise training prevented this decrease. We did not find significant changes in COX4, SIRT3, PGC-1a or GLUT4 levels, while the changes in pAMPK/AMPK, pmTOR/mTOR, pS6/S6 and NRF2 levels were randomly modulated. The data suggest that exercise and probiotics-induced changes in microbiome do not strongly affect mitochondrial density or protein synthesis-related AMPK/mTOR/S6 pathways in the liver of these animals.
已经证明，体育锻炼和益生菌补充可以延缓 APP/PS1 雄性小鼠阿尔茨海默病（AD）的进展。然而，也有人认为运动和 AD 都具有全身性影响。我们研究了运动训练和益生菌治疗对肝脏微生物组和生化信号蛋白的影响。结果表明，肝脏处于氧化应激状态，因为与野生型小鼠相比，APP/PS1 小鼠的 SOD2 水平降低。运动训练防止了这种降低。我们没有发现 COX4、SIRT3、PGC-1a 或 GLUT4 水平的显著变化，而 pAMPK/AMPK、pmTOR/mTOR、pS6/S6 和 NRF2 水平的变化则是随机调节的。数据表明，运动和益生菌诱导的微生物组变化不会强烈影响这些动物肝脏中线粒体密度或与蛋白合成相关的 AMPK/mTOR/S6 通路。
