Department of Respiratory Medicine, 56647The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China.
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820947482. doi: 10.1177/1533033820947482.
To evaluate the diagnostic value of radial endobronchial ultrasound (R-EBUS) combination with rapid on-site evaluation (ROSE) guided transbronchial lung biopsy (TBLB) for peripheral pulmonary lesions.
Peripheral pulmonary lesions identified by computed tomography underwent R-EBUS with or without ROSE randomly from February 2016 to August 2017. The diagnostic yield and the operation time were compared.
In total, 158 patients were involved in and completed this research, including 84 cases in the group of R-EBUS with ROSE, and 74 in the group without ROSE. The diagnostic yield of ROSE group was 85.7%. Among these positive cases, 69.4% cases were malignant tumors, and 30.6% cases were benign lesions. The operation time was (24.6 ± 6.3) min. In the group without ROSE, the diagnostic yield was 70.3%, including 35 malignant tumors (67.3%), and 17 benign lesions (32.7%). The operation time was (31.5 ± 6.8) min. There were significant differences between both groups in the diagnostic yield (χ2 = 5.556, P = 0.018) and in the operation time (t = 3.187, P < 0.01). No serious procedure related complications were observed, such as pneumothorax and hemorrhage.
ROSE can improve the diagnostic yield, and shorten the operation time. R-EBUS combined with ROSE is a safe and effective technique for peripheral pulmonary lesions.
评估径向支气管内超声（R-EBUS）联合快速现场评估（ROSE）引导经支气管肺活检（TBLB）对周围性肺部病变的诊断价值。
2016 年 2 月至 2017 年 8 月，对 CT 发现的周围性肺部病变患者，随机采用 R-EBUS 联合或不联合 ROSE 进行检查。比较两种方法的诊断阳性率和操作时间。
共有 158 例患者参与并完成了这项研究，其中 R-EBUS 联合 ROSE 组 84 例，不联合 ROSE 组 74 例。ROSE 组的诊断阳性率为 85.7%。在这些阳性病例中，69.4%为恶性肿瘤，30.6%为良性病变。操作时间为（24.6±6.3）min。在不联合 ROSE 组，诊断阳性率为 70.3%，包括 35 例恶性肿瘤（67.3%）和 17 例良性病变（32.7%）。操作时间为（31.5±6.8）min。两组在诊断阳性率（χ2=5.556，P=0.018）和操作时间（t=3.187，P<0.01）方面差异均有统计学意义。无严重与操作相关的并发症，如气胸和出血。
ROSE 可提高诊断阳性率，缩短操作时间。R-EBUS 联合 ROSE 是一种安全有效的周围性肺部病变诊断技术。
