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1
Long-term outcomes of juvenile-onset recurrent respiratory papillomatosis.青少年复发性呼吸道乳头瘤病的长期结局。
Clin Otolaryngol. 2021 Jan;46(1):161-167. doi: 10.1111/coa.13635. Epub 2020 Sep 17.
2
Laryngeal sequelae secondary to surgical treatment for recurrent respiratory papillomatosis in children.儿童复发性呼吸道乳头状瘤病手术治疗后的喉部后遗症。
Int J Pediatr Otorhinolaryngol. 2020 Mar;130:109815. doi: 10.1016/j.ijporl.2019.109815. Epub 2019 Dec 14.
3
Postoperative Systemic Acyclovir in Juvenile-Onset Recurrent Respiratory Papillomatosis: The Outcome.青少年复发性呼吸道乳头状瘤病术后全身使用阿昔洛韦:结果
Ear Nose Throat J. 2019 Jan;98(1):28-31. doi: 10.1177/0145561318823311. Epub 2019 Jan 30.
4
[Analysis of long-term effect of juvenile-onset recurrent respiratory papillomatosis].[青少年复发性呼吸道乳头状瘤病的长期疗效分析]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Nov 7;53(11):825-829. doi: 10.3760/cma.j.issn.1673-0860.2018.11.006.
5
Recurrent respiratory papillomatosis: update 2018.复发性呼吸道乳头状瘤病:2018年更新
Curr Opin Otolaryngol Head Neck Surg. 2018 Dec;26(6):421-425. doi: 10.1097/MOO.0000000000000490.
6
[CT findings of juvenile laryngeal papilloma spreading in bronchia and lung].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 May;32(10):767-769. doi: 10.13201/j.issn.1001-1781.2018.10.010.
7
Current and future management of recurrent respiratory papillomatosis.复发性呼吸道乳头状瘤病的当前及未来管理
Laryngoscope Investig Otolaryngol. 2018 Jan 14;3(1):22-34. doi: 10.1002/lio2.132. eCollection 2018 Feb.
8
Quality of life of young patients with recurrent respiratory papillomatosis.复发性呼吸道乳头状瘤病年轻患者的生活质量
J Laryngol Otol. 2017 May;131(5):425-428. doi: 10.1017/S0022215117000354. Epub 2017 Feb 14.
9
Recurrent respiratory papillomatosis: current and future perspectives.复发性呼吸道乳头状瘤病:现状与未来展望
Ther Clin Risk Manag. 2015 May 5;11:731-8. doi: 10.2147/TCRM.S81825. eCollection 2015.
10
Laryngotracheal stenosis as a complication of photodynamic therapy.
Ann Otol Rhinol Laryngol. 2015 Jun;124(6):495-8. doi: 10.1177/0003489415570930. Epub 2015 Feb 9.

[青少年复发性呼吸道乳头状瘤病术后并发症相关因素分析]

[Analysis of related factors of postoperative complications of Juvenile-onset recurrent respiratory papillomatosis].

作者信息

Shen Mengya, Xiao Yang, Ma Lijing, Wang Jun

机构信息

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Apr;35(4):312-315. doi: 10.13201/j.issn.2096-7993.2021.04.006.

DOI:10.13201/j.issn.2096-7993.2021.04.006
PMID:33794627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10128438/
Abstract

To analyze the causes and related factors of postoperative complications of Juvenile-onset recurrent respiratory papillomatosis(JORRP). One hundred and seventy cases of JORRP who underwent surgical treatment in Beijing Tongren Hospital of Capital Medical University from 2017 to 2019 were followed up, and the types of complications, age of first operation, number and frequency of operations, and underwent tracheotomy or not were reviewed. According to the presence or absence of postoperative complications, the patients were divided into a complication group and a control group, and the differences between the two groups and related factors causing postoperative complications were compared. In the 170 cases, 75(44.12%) had postoperative complications, including 52(69.33%) cases of vocal cord adhesion, 37(49.33%) cases of lower airway diffusion, and 25(33.33%) cases of laryngeal stenosis in the complication group. The age of first operation was among 0.3-14 years old, and the total number of surgeries was 14.52(1-54) for each patient during the observation period, with an average annual number of 2.93(0.04-18.39). Compared with the control group, the complication group had 19.07±13.12 total surgeries, the control group had 10.97±9.41 surgeries(<0.01), annual surgeries ≥4 times(=0.034), postoperative complications after tracheotomy(=0.007), and underwent low temperature plasma radiofrequency ablation and photodynamic therapy were more likely to occur than those treated with CO2laser only(<0.01). The postoperative complications of JORRP include vocal cord adhesion, laryngotracheal stenosis, lower airway dissemination, etc. Multiple and frequent operations, tracheotomy, and different surgical methods are closely related to postoperative complications. The risk of postoperative complications may be increased when children are younger in age of initial operation and with more frequency of surgeries.

摘要

分析儿童复发性呼吸道乳头状瘤病(JORRP)术后并发症的原因及相关因素。对2017年至2019年在首都医科大学附属北京同仁医院接受手术治疗的170例JORRP患者进行随访,回顾并发症类型、首次手术年龄、手术次数及频率、是否行气管切开术等情况。根据术后有无并发症将患者分为并发症组和对照组,比较两组间差异及导致术后并发症的相关因素。170例患者中,75例(44.12%)发生术后并发症,并发症组中声带粘连52例(69.33%)、下气道播散37例(49.33%)、喉狭窄25例(33.33%)。首次手术年龄在0.3 - 14岁之间,观察期内每位患者手术总数为14.52(1 - 54)次,平均每年2.93(0.04 - 18.39)次。与对照组相比,并发症组手术总数为19.07±13.12次,对照组为10.97±9.41次(P<0.01),每年手术≥4次(P = 0.034),气管切开术后发生并发症(P = 0.007),且接受低温等离子体射频消融和光动力治疗的患者比仅接受CO₂激光治疗的患者更易发生并发症(P<0.01)。JORRP术后并发症包括声带粘连、喉气管狭窄、下气道播散等。手术次数多且频繁、气管切开术及不同手术方式与术后并发症密切相关。初次手术年龄较小及手术频率较高的儿童术后并发症风险可能增加。