Larsson L I, Sundler F, Alumets J, Håkanson R, Schaffalitzky de Muckadell O B, Fahrenkrug J
Cell Tissue Res. 1977 Jul 15;181(3):361-8. doi: 10.1007/BF00223111.
Immunocytochemically, secretin cells have been demonstrated to occur in the duodenum and jejunum of several mammals. Calculations on the relative frequency of such cells indicate that the bulk of secretin occurs in the jejunum, a fact supporting the view that secretin may be released by physiological stimulants other than hydrochloric acid. Electron microscopical identification of cat and pig secretin cells confirmed their identity with the ultrastructurally defined S cells, and staining experiments revealed that secretin cells were argyrophilic both with the method of Grimelius and with that of Hellerström and Hellman. Secretin cells are detected already in the 17-day old fetal rat duodenum and show a developmental pattern similar to that displayed by the gastrin cells. It is suggested that secretin may play a role in the early regulation of growth of the fetal gastrointestinal tract.
免疫细胞化学研究表明，促胰液素细胞存在于多种哺乳动物的十二指肠和空肠中。对这类细胞相对频率的计算表明，大部分促胰液素存在于空肠中，这一事实支持了促胰液素可能由盐酸以外的生理刺激物释放的观点。对猫和猪促胰液素细胞的电子显微镜鉴定证实了它们与超微结构定义的S细胞一致，染色实验表明，促胰液素细胞用格里梅利乌斯法和赫勒斯特伦与赫尔曼法染色均呈嗜银性。在17日龄的胎鼠十二指肠中已检测到促胰液素细胞，其发育模式与胃泌素细胞相似。有人认为，促胰液素可能在胎儿胃肠道生长的早期调节中起作用。
