The Institute of Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
The Institute of Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
Biotechnol Adv. 2020 Nov 15;44:107611. doi: 10.1016/j.biotechadv.2020.107611. Epub 2020 Aug 18.
Surface active magnetic nanoparticles especially superparamagnetic iron oxides are already occupying a major domain in medical therapeutics. Arresting of these magnetic nanoparticles into polymer hydrogel is a spatial assembly of nanoparticles that serves the precise delivery of drug molecules. Magnetic hydrogels are very less cultured area still in the biomedical field. This review embraces how the external magnetic field (either static or oscillating) affects the payload release from the hydrogel matrix and their magneto-regulative deformation. Besides these, we also discussed how the ferrosponge and biphasic ferrogel based scaffold type systems impact over the release kinetics and tunability of drug release behaviours.
表面活性磁性纳米粒子，特别是超顺磁性氧化铁，已经在医学治疗领域占据了主要地位。将这些磁性纳米粒子固定在聚合物水凝胶中是纳米粒子的空间组装，用于精确递送药物分子。磁性水凝胶在生物医学领域仍然是一个研究较少的领域。本综述探讨了外磁场（无论是静态还是振荡）如何影响水凝胶基质中有效负载的释放及其磁调节变形。除此之外，我们还讨论了基于铁海绵和双相铁凝胶的支架型系统如何影响药物释放动力学和释放行为的可调性。
