Department of Anesthesiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, PR China.
Department of Basic Medicine, Wuxi Medical School, Jiangnan University, Wuxi 214122, PR China; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Gene. 2020 Dec 30;763:145066. doi: 10.1016/j.gene.2020.145066. Epub 2020 Aug 19.
Diabetes is characterized by changed homeostasis of blood glucose levels, which is associated with various complications, including cardiomyopathy, atherosclerosis, endothelial dysfunction, nephropathy, retinopathy and neuropathy. In recent years, accumulative evidence has demonstrated that circular RNAs are identified as a novel type of noncoding RNAs (ncRNAs) involving in the regulation of various physiological processes and pathologic conditions. Specifically, the emergence of complications response to diabetes is finely controlled by a complex gene regulatory network in which circular RNAs play a critical role. Recently, circular RNAs are emerging as messengers that could influence cellular functions under diabetic conditions. Dysregulation of circular RNAs has been closely linked to the pathophysiology of diabetes-related complications. In this review, we aimed to summarize the current progression and underlying mechanisms of circular RNA in the development of diabetes-related complications. We will also provide an overview of circular RNA-regulated cell communications in different types of cells that have been linked to diabetic complications. We anticipated that the completion of this review will provide potential clues for developing novel circular RNAs-based biomarkers or therapeutic targets for diabetes and its associated complications.
糖尿病的特征是血糖水平的动态平衡发生改变，这与多种并发症有关，包括心肌病、动脉粥样硬化、内皮功能障碍、肾病、视网膜病变和神经病变。近年来，越来越多的证据表明，环状 RNA 被鉴定为一种新型的非编码 RNA（ncRNA），参与调节各种生理过程和病理状况。具体来说，糖尿病并发症的出现是由一个复杂的基因调控网络精细控制的，环状 RNA 在其中发挥着关键作用。最近，环状 RNA 作为信使，在糖尿病等疾病条件下影响细胞功能。环状 RNA 的失调与糖尿病相关并发症的病理生理学密切相关。在这篇综述中，我们旨在总结环状 RNA 在糖尿病相关并发症发展过程中的最新进展和潜在机制。我们还将概述与糖尿病并发症相关的不同类型细胞中环状 RNA 调节的细胞通讯。我们预计，完成这项综述将为开发基于环状 RNA 的新型生物标志物或治疗靶点提供潜在的线索，用于治疗糖尿病及其相关并发症。
