Tai Ruei-Yi, Zhu Jun-Ding, Cheng Chia-Hsiung, Tseng Yi-Jhan, Chen Chih-Chi, Hsieh Yu-Wei
Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan; Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan.
Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Clin Neurophysiol. 2020 Oct;131(10):2333-2340. doi: 10.1016/j.clinph.2020.06.030. Epub 2020 Jul 22.
This study aimed to investigate the differential effects of bilateral and unilateral mirror therapy (MT) on motor cortical activations in stroke patients by magnetoencephalography (MEG).
Sixteen stroke patients and 16 right-handed healthy volunteers were recruited. All participants were required to perform 4 conditions: resting, no mirror with bilateral hand movements (Bilateral-No mirror), mirror with bilateral hand movements (Bilateral-Mirror) and mirror with unilateral hand movements (Unilateral-Mirror). Beta oscillatory activities in the primary motor cortex (M1) were collected during each condition using MEG. The percentage change of beta oscillatory activity was calculated for each condition to correct the baseline differences.
In the stroke group, the percentage change of M1 beta oscillatory activity significantly decreased more in the Bilateral-Mirror condition than in the Bilateral-No mirror and Unilateral-Mirror conditions. In the healthy group, no significant differences in the percentage change of beta oscillatory activity were found among the 3 conditions. Further, a significant difference in the percentage change of beta oscillatory activity only in the Bilateral-Mirror condition was found between the 2 groups.
This study provides new information on the differential cortical activations modulated by bilateral and unilateral MT.
Bilateral MT led to greater M1 neural activities than unilateral MT and bilateral movements without a mirror in stroke patients.
本研究旨在通过脑磁图（MEG）研究双侧和单侧镜像疗法（MT）对中风患者运动皮质激活的不同影响。
招募了16名中风患者和16名右利手健康志愿者。所有参与者都被要求执行4种情况：静息、双侧手部运动无镜像（双侧-无镜像）、双侧手部运动有镜像（双侧-镜像）和单侧手部运动有镜像（单侧-镜像）。在每种情况下使用MEG收集初级运动皮层（M1）中的β振荡活动。计算每种情况下β振荡活动的百分比变化以校正基线差异。
在中风组中，双侧-镜像情况下M1β振荡活动的百分比变化比双侧-无镜像和单侧-镜像情况下显著下降更多。在健康组中，3种情况下β振荡活动百分比变化未发现显著差异。此外，两组之间仅在双侧-镜像情况下β振荡活动百分比变化存在显著差异。
本研究提供了关于双侧和单侧MT调节的不同皮质激活的新信息。
在中风患者中，双侧MT比单侧MT和无镜像的双侧运动导致更大的M1神经活动。
