Modulated mesenchymal stromal cells improve skin wound healing.

Mesenchymal stromal cells (MSCs, also known as mesenchymal stem cells) are considered to be promising candidates for cell-based therapy of numerous skin disorders and wound healing. It is believed that MSCs differentiation into epithelial cells fill the area of the wound, while secretion of paracrine factors regulates cell homeostasis and adaptation. MSCs have been found to accelerate wound healing and recovery of skin appendages, however, it has been stated that the majority of exogenously applied MSCs may not survive nor were detectable incorporated in the target area. These ambivalent data of localization and persistence of MSCs after their administration evoke some doubts about the effectiveness of MSCs. To elucidate these ambiguities and overcome the problem, different methods of improving the survival and homing capacity of MSCs have been developed. This article will review research data and strategies that may increase MSC's therapeutic efficacy in aging and damaged skin.