Department of Veterinary Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Next Generation Sequencing Platform, Institute of Genetics, Vetsuisse, University of Bern, Bern, Switzerland.
J Fish Dis. 2020 Oct;43(10):1115-1132. doi: 10.1111/jfd.13237. Epub 2020 Aug 23.
Tilapia lake virus (TiLV) is a highly contagious pathogen that has detrimental effects on tilapia farming. This virus was discovered in 2014 and has received tremendous global attention from the aquaculture sector due to its association with high fish mortalities and its strong economic impact on the tilapia aquaculture industry. Currently, TiLV has been reported in 16 countries, and this number is continuing to rise due to improved diagnostic assays and surveillance activities around the world. In this review, we summarize the up-to-date knowledge of TiLV with regard to TiLV host species, the clinical signs of a TiLV infection, the affected tissues, pathogenesis and potential disease risk factors. We also describe the reported information concerning the virus itself: its morphology, genetic make-up and transmission pathways. We review the current methods for virus detection and potential control measures. We close the review of the TiLV story so far, by offering a commentary on the major TiLV research gaps, why these are delaying future TiLV research and why the TiLV field needs to come together and proceed as a more collaborative scientific community if there is any hope limiting the impact of this serious virus.
罗非鱼湖病毒（TiLV）是一种具有高度传染性的病原体，对罗非鱼养殖有不利影响。该病毒于 2014 年被发现，由于其与高鱼类死亡率有关，并且对罗非鱼养殖业具有很强的经济影响，因此引起了全球水产养殖业的极大关注。目前，TiLV 已在 16 个国家报告，由于全球诊断检测和监测活动的改进，该数字还在继续增加。在这篇综述中，我们总结了 TiLV 的最新知识，包括 TiLV 的宿主物种、TiLV 感染的临床症状、受影响的组织、发病机制和潜在的疾病危险因素。我们还描述了有关该病毒本身的报告信息：其形态、遗传组成和传播途径。我们回顾了当前的病毒检测方法和潜在的控制措施。最后，我们对 TiLV 的研究进行了评论，讨论了 TiLV 研究中的主要空白，为什么这些空白会延迟未来的 TiLV 研究，以及为什么 TiLV 领域需要团结起来，作为一个更具协作性的科学界前进，如果有任何希望限制这种严重病毒的影响的话。
