He Mengni, Henderson MacKenzie, Muth Stephen, Murphy Adrian, Zheng Lei
Department of Cell Biology, Baltimore, MD, USA.
Department of Oncology, Baltimore, MD, USA.
Ann Pancreat Cancer. 2020 Jul;3. doi: 10.21037/apc.2020.03.03. Epub 2020 Jul 22.
Pancreatic ductal adenocarcinoma (PDAC) is in urgent need of better diagnostic and therapeutic methods due to its late diagnosis, limited treatment options and poor prognosis. Finding the right animal models to recapitulate the tumor molecular pathogenesis and tumor microenvironment (TME) complexity is critical for preclinical immunotherapeutic and non-immunotherapeutic treatment developments. In this review, we summarize and evaluate popular preclinical animal models including patient-derived xenograft models, humanized mouse models, genetically engineered mouse models, and syngeneic mouse models. Through comparisons between these models in different research settings, we hope to provide guidance in finding the most relevant preclinical models to suit various research purposes.
胰腺导管腺癌（PDAC）由于其诊断较晚、治疗选择有限且预后较差，迫切需要更好的诊断和治疗方法。找到合适的动物模型来重现肿瘤分子发病机制和肿瘤微环境（TME）的复杂性对于临床前免疫治疗和非免疫治疗的发展至关重要。在本综述中，我们总结并评估了常用的临床前动物模型，包括患者来源的异种移植模型、人源化小鼠模型、基因工程小鼠模型和同基因小鼠模型。通过在不同研究背景下对这些模型进行比较，我们希望为寻找最适合各种研究目的的相关临床前模型提供指导。
