卫星征对脑出血血肿扩大的预测准确性：一项荟萃分析。
The predictive accuracy of satellite sign for hematoma expansion in intracerebral hemorrhage: A meta-analysis.
机构信息
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Tongji Medical College, Huazhong University of Science and Technology, Wuhan Mental Health Centre, Wuhan Hospital for Psychotherapy, Wuhan, China.
出版信息
Clin Neurol Neurosurg. 2020 Oct;197:106139. doi: 10.1016/j.clineuro.2020.106139. Epub 2020 Aug 7.
BACKGROUND AND PURPOSE
Satellite sign is a novel neuroimaging marker for predicting hematoma expansion (HE), which is closely related to unfavorable prognosis in patients with spontaneous intracerebral hemorrhage (ICH). However, the predictive value of satellite sign varied according to previous studies. Thus, we conduct this meta-analysis to systematically review the application value of satellite sign in related studies.
METHODS
We searched the literature in PubMed, Embase, and Web of Science from inception to April 10, 2020. Effect values, including sensitivity, specificity, and positive and negative likelihood ratio were pooled to assess the diagnostic value of satellite sign for HE in patients with ICH.
RESULTS
The meta-analysis included five studies with a total of 1493 patients. Results showed that the pooled diagnostic sensitivity and specificity were 0.50 (95 % CI, 0.31-0.70) and 0.71 (95 % CI, 0.56-0.83), respectively. In addition, the pooled positive and negative likelihood ratios were 1.7 (95 % CI, 1.5-2.1) and 0.70 (95 % CI, 0.54-0.89), respectively. No significant publication bias was found.
CONCLUSION
Satellite sign exhibited moderate sensitivity and specificity for predicting HE in patients with ICH. Further studies are needed to explore its value in clinical application.
背景与目的
卫星征是一种新的神经影像学标志物，可用于预测血肿扩大（HE），与自发性脑出血（ICH）患者的不良预后密切相关。然而，卫星征的预测价值因先前的研究而有所不同。因此，我们进行了这项荟萃分析，以系统地综述卫星征在相关研究中的应用价值。
方法
我们检索了从建库至 2020 年 4 月 10 日PubMed、Embase 和 Web of Science 中的文献。汇总了效应值，包括敏感度、特异度、阳性和阴性似然比，以评估卫星征对 ICH 患者 HE 的诊断价值。
结果
荟萃分析纳入了 5 项研究，共 1493 例患者。结果显示，合并诊断敏感度和特异度分别为 0.50（95%CI，0.31-0.70）和 0.71（95%CI，0.56-0.83）。此外，合并阳性和阴性似然比分别为 1.7（95%CI，1.5-2.1）和 0.70（95%CI，0.54-0.89）。未发现明显的发表偏倚。
结论
卫星征对预测 ICH 患者的 HE 具有中等的敏感度和特异度。需要进一步的研究来探讨其在临床应用中的价值。
Zotero 插件