MEG Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Neuroimage Clin. 2020;28:102378. doi: 10.1016/j.nicl.2020.102378. Epub 2020 Aug 8.
Major depressive disorder (MDD) is highly heterogeneous in its clinical presentation. The present exploratory study used magnetoencephalography (MEG) to investigate electrophysiological intrinsic connectivity differences between healthy volunteers and unmedicated participants with treatment-resistant MDD. The study examined canonical frequency bands from delta through gamma. In addition to group comparisons, correlational studies were conducted to determine whether connectivity was related to five symptom factors: depressed mood, tension, negative cognition, suicidal thoughts, and amotivation. The MDD and healthy volunteer groups did not differ significantly at baseline when corrected across all frequencies and clusters, although evidence of generalized slowing in MDD was observed. Notably, however, electrophysiological connectivity was strongly related to suicidal thoughts, particularly as coupling of low frequency power fluctuations (delta and theta) with alpha and beta power. This analysis revealed hub areas underlying this symptom cluster, including left hippocampus, left anterior insula, and bilateral dorsolateral prefrontal cortex. No other symptom cluster demonstrated a relationship with neurophysiological connectivity, suggesting a specificity to these results as markers of suicidal ideation.
重度抑郁症（MDD）在临床表现上高度异质。本探索性研究使用脑磁图（MEG）来研究健康志愿者和未经治疗的抗药性 MDD 参与者之间电生理固有连接的差异。该研究检查了从 delta 到 gamma 的典型频带。除了组间比较外，还进行了相关性研究，以确定连接是否与五个症状因素相关：抑郁情绪、紧张、消极认知、自杀念头和动机缺乏。在纠正所有频率和聚类后，MDD 组和健康志愿者组在基线时没有显著差异，尽管观察到 MDD 中存在广泛的减速现象。然而，值得注意的是，电生理连接与自杀念头密切相关，尤其是低频功率波动（delta 和 theta）与 alpha 和 beta 功率的耦合。该分析揭示了该症状群的潜在核心区域，包括左海马体、左前岛叶和双侧背外侧前额叶皮层。没有其他症状群与神经生理连接表现出相关性，这表明这些结果作为自杀意念的标志物具有特异性。
