Ballard Elizabeth D, Gilbert Jessica R, Wusinich Christina, Zarate Carlos A
Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Front Psychiatry. 2021 Jan 26;12:598434. doi: 10.3389/fpsyt.2021.598434. eCollection 2021.
Rapid-acting interventions for the suicide crisis have the potential to transform treatment. In addition, recent innovations in suicide research methods may similarly expand our understanding of the psychological and neurobiological correlates of suicidal thoughts and behaviors. This review discusses the limitations and challenges associated with current methods of suicide risk assessment and presents new techniques currently being developed to measure rapid changes in suicidal thoughts and behavior. These novel assessment strategies include ecological momentary assessment, digital phenotyping, cognitive and implicit bias metrics, and neuroimaging paradigms and analysis methodologies to identify neural circuits associated with suicide risk. This review is intended to both describe the current state of our ability to assess rapid changes in suicide risk as well as to explore future directions for clinical, neurobiological, and computational markers research in suicide-focused clinical trials.
针对自杀危机的快速干预措施有可能改变治疗方式。此外，自杀研究方法的最新创新同样可能拓展我们对自杀想法和行为的心理及神经生物学关联的理解。本综述讨论了当前自杀风险评估方法的局限性和挑战，并介绍了目前正在开发的用于测量自杀想法和行为快速变化的新技术。这些新颖的评估策略包括生态瞬时评估、数字表型分析、认知和内隐偏见指标，以及用于识别与自杀风险相关神经回路的神经成像范式和分析方法。本综述旨在描述我们评估自杀风险快速变化能力的当前状态，并探索以自杀为重点的临床试验中临床、神经生物学和计算标志物研究的未来方向。
