Harcup J W, Tooley P J
The Surgery, Twyford, Berks, England.
Pharmatherapeutica. 1988;5(3):145-51.
An open, multi-centre study was carried out to assess the efficacy and acceptability of an ointment formulation of 2% miconazole and 1% hydrocortisone ('Daktacort') in 73 patients with eczematous lesions, with or without bacterial superinfection. Patients were instructed to apply the ointment to the lesions morning and evening for 14 days; those with residual lesions were asked to continue treatment for a further 14 days. Assessments of the severity of the patients' symptoms were made by investigators before and after 7 and 14 days of treatment, and a global evaluation of response was made at the end of the treatment period. Patients kept a daily diary for 14 days in which they recorded the severity of their symptoms, acceptability of the ointment and details of any problems associated with treatment. Investigator rating of pruritus, weeping/bleeding, scaling, crusting, erythema, excoriation and burning/pain showed a significant improvement in these symptoms after 7 days and global assessment showed 85% of patients had responded after 14 days of treatment. Patient assessment using a diary card confirmed this improvement, and 96% found the ointment to be an acceptable form of treatment.
开展了一项开放性多中心研究，以评估2%咪康唑和1%氢化可的松软膏制剂（“达克宁皮质”）对73例有或无细菌叠加感染的湿疹性皮损患者的疗效和可接受性。患者被指示早晚将软膏涂抹于皮损处，持续14天；有残留皮损的患者被要求继续治疗14天。研究者在治疗7天和14天前后对患者症状的严重程度进行评估，并在治疗期结束时对反应进行整体评估。患者连续14天记录日记，记录其症状的严重程度、软膏的可接受性以及与治疗相关的任何问题的细节。研究者对瘙痒、渗液/出血、脱屑、结痂、红斑、表皮剥脱和灼痛/疼痛的评分显示，7天后这些症状有显著改善，整体评估显示，治疗14天后85%的患者有反应。使用日记卡进行的患者评估证实了这种改善，96%的患者认为该软膏是一种可接受的治疗形式。
