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结膜炎作为新型冠状病毒感染的哨兵:对轻微症状的重新审视需求

Conjunctivitis as a Sentinel of SARS-CoV-2 Infection: a Need of Revision for Mild Symptoms.

作者信息

Panoutsopoulos Alexios A

机构信息

Department of Pathology and Laboratory Medicine, University of California, Davis, CA USA.

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Northern California, 2425 Stockton Boulevard, Sacramento, CA 95817 USA.

出版信息

SN Compr Clin Med. 2020;2(7):859-864. doi: 10.1007/s42399-020-00360-7. Epub 2020 Jun 19.

Abstract

COVID-19 has been declared a pandemic by the World Health Organization on March 11, and since then, more than 3 million cases and a quarter million deaths have occurred due to it. Lately, there is a growing evidence for an ophthalmologic symptom (conjunctivitis) to be connected with the disease. This seems to happen in early stages of the infection by SARS-CoV-2, and thus, it is of major importance to understand the mechanism through which the virus can facilitate such a symptom. Here, we are proposing a molecular mechanism through which the novel coronavirus could act in order to affect the eye and use it as another, secondary but alternative, point of entry to the host organism.

摘要

3月11日,世界卫生组织宣布新型冠状病毒肺炎(COVID-19)为大流行病,自那时以来,因该疾病已导致超过300万例病例和25万人死亡。最近,越来越多的证据表明一种眼科症状(结膜炎)与该疾病有关。这似乎发生在严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染的早期阶段,因此,了解病毒引发这种症状的机制至关重要。在此,我们提出一种分子机制,新型冠状病毒可能通过该机制作用于眼睛,并将其作为进入宿主生物体的另一个次要但可替代的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406b/7303432/758cc8d727a2/42399_2020_360_Fig1_HTML.jpg

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