Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390
J Immunol. 2020 Sep 1;205(5):1189-1197. doi: 10.4049/jimmunol.2000439.
Thermal injury is often associated with a proinflammatory state resulting in serious complications. After a burn, the innate immune system is activated with subsequent immune cell infiltration and cytokine production. Although the innate immune response is typically beneficial, an excessive activation leads to cytokine storms, multiple organ failure, and even death. This overwhelming immune response is regulated by damage-associated molecular patterns (DAMPs). DAMPs are endogenous molecules that are actively secreted by immune cells or passively released by dead or dying cells that can bind to pathogen recognition receptors in immune and nonimmune cells. Recent studies involving animal models along with human studies have drawn great attention to the possible pathological role of DAMPs as an immune consequence of thermal injury. In this review, we outline DAMPs and their function in thermal injury, shedding light on the mechanism of sterile inflammation during tissue injury and identifying new immune targets for treating thermal injury.
热烧伤常伴有促炎状态，导致严重并发症。烧伤后，先天免疫系统被激活，随后免疫细胞浸润和细胞因子产生。虽然先天免疫反应通常是有益的，但过度激活会导致细胞因子风暴、多器官衰竭，甚至死亡。这种压倒性的免疫反应受损伤相关分子模式（DAMPs）的调节。DAMPs 是由免疫细胞主动分泌或死亡或垂死细胞被动释放的内源性分子，可与免疫和非免疫细胞中的病原体识别受体结合。最近涉及动物模型和人体研究的研究引起了人们对 DAMPs 作为热烧伤免疫后果的可能病理作用的极大关注。在这篇综述中，我们概述了 DAMPs 及其在热损伤中的功能，阐明了组织损伤过程中无菌性炎症的机制，并确定了治疗热损伤的新免疫靶点。
