Yang Jing, Zheng Lei, Guan Yu-Yao, Lv Yong-Tao
School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Department of Pharmacy, Shandong Medical College, Jinan, China.
Front Pharmacol. 2022 Jul 22;13:829408. doi: 10.3389/fphar.2022.829408. eCollection 2022.
This study aimed to investigate the key points in the transformation of the functions of the Drug and Therapeutics Committee (DTC) of the Shandong Provincial Third Hospital and how to provide full authority to its role in the control of rational drug use, especially in the management of antibiotic use. A prescription review management group, antimicrobial stewardship group, and rational drug use service group were established under the DTC. From January 2016 to December 2021, each group played a role in promoting rational drug use and antimicrobial stewardship. In addition, we performed statistics on typical management cases, irrational drug use, bacterial resistance rate, and drug costs from 2015 to 2021 to evaluate the effect of management by the DTC. Intervention by the DTC led to a significant reduction in prescribing errors (71.43%, < 0.05), the intervention acceptance rate increased by 16.03%, and the problem solved rate increased by 32.41% ( < 0.05). Resistance rates of general spectrum antibiotics were reduced remarkably after the intervention. The quality of drug treatment was improved and patient drug expenses was continuously reduced. Giving full play to the functions of the DTC can significantly improve the level of drug treatment and reduce unreasonable drug use to save unnecessary drug expenses and slow the development of drug resistance.
本研究旨在探讨山东省立第三医院药事与治疗学委员会（DTC）职能转变的关键点，以及如何充分发挥其在合理用药控制，尤其是抗生素使用管理方面的作用。在DTC下设处方点评管理组、抗菌药物管理组和合理用药服务组。2016年1月至2021年12月，各组在促进合理用药和抗菌药物管理方面发挥了作用。此外，我们对2015年至2021年的典型管理案例、不合理用药情况、细菌耐药率和药品费用进行了统计，以评估DTC的管理效果。DTC的干预使处方差错显著减少（71.43%，<0.05），干预接受率提高了16.03%，问题解决率提高了32.41%（<0.05）。干预后广谱抗生素的耐药率显著降低。药物治疗质量得到提高，患者药品费用持续降低。充分发挥DTC的职能可以显著提高药物治疗水平，减少不合理用药，节省不必要的药品费用，减缓耐药性的发展。
