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临床推理:一名患有痴呆、失禁和步态功能障碍的75岁男性。

Clinical Reasoning: A 75-Year-Old Man With Dementia, Incontinence, and Gait Dysfunction.

作者信息

Richter Kent R, Naylor Ryan, Cutsforth-Gregory Jeremy K, Elder Benjamin D

机构信息

Neurosurgery, Mayo Clinic Alix School of Medicine, Mayo Clinic, Phoenix, USA.

Neurosurgery, Mayo Clinic, Rochester, USA.

出版信息

Cureus. 2020 Jul 21;12(7):e9311. doi: 10.7759/cureus.9311.

Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is a progressive neurological disorder characterized by gait apraxia, cognitive decline, and urinary incontinence. It can be difficult to diagnose iNPH as the symptoms may overlap with other neurodegenerative diseases including ​cervical spondylotic myelopathy. Cervical spondylotic myelopathy is a progressive degenerative disease in which compression of the cervical spinal cord causes gait disturbances and imbalance, loss of dexterity and strength in the hands, and, at late stages, urinary dysfunction. As with iNPH, increased age is associated with higher incidence and prevalence. Surgical decompression of the cervical spinal cord is the treatment of choice in patients with progressive myelopathy. Accordingly, iNPH and cervical myelopathy may both present with progressive gait impairment and incontinence, especially in the elderly. The case presented here demonstrates that both iNPH and cervical myelopathy may present simultaneously and result in gait disturbances and imbalance in some patients. For patients with suspected iNPH and myelopathic findings on examination, it is prudent to obtain a cervical spine MRI to assess for cervical stenosis. Moreover, cervical stenosis can mask the effect of cerebrospinal fluid diversion in patients with comorbid iNPH and cervical myelopathy. Therefore, the differential for patients who have symptomology suggestive of iNPH should include cervical spine myelopathy, with considerations for possible cervical decompression in addition to placement of a ventriculoperitoneal shunt.

摘要

特发性正常压力脑积水(iNPH)是一种进行性神经疾病,其特征为步态失用、认知功能减退和尿失禁。iNPH可能难以诊断,因为其症状可能与包括脊髓型颈椎病在内的其他神经退行性疾病重叠。脊髓型颈椎病是一种进行性退行性疾病,其中颈椎脊髓受压会导致步态障碍和失衡、手部灵活性和力量丧失,以及在疾病后期出现排尿功能障碍。与iNPH一样,年龄增长与发病率和患病率升高相关。颈椎脊髓减压手术是进行性脊髓病患者的首选治疗方法。因此,iNPH和颈椎脊髓病都可能表现为进行性步态障碍和尿失禁,尤其是在老年人中。本文介绍的病例表明,iNPH和颈椎脊髓病可能同时出现,并导致一些患者出现步态障碍和失衡。对于检查发现疑似iNPH和脊髓病表现的患者,谨慎起见应进行颈椎MRI检查以评估是否存在颈椎管狭窄。此外,颈椎管狭窄可能会掩盖合并iNPH和颈椎脊髓病患者脑脊液分流的效果。因此,对于有提示iNPH症状的患者,鉴别诊断应包括颈椎脊髓病,除了放置脑室腹腔分流管外,还应考虑可能的颈椎减压。

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