National Center for Nanoscience and Technology, The University of Chinese Academy of Sciences, No. 11 Zhongguancun Beiyitiao, Beijing, 100190, P. R. China.
Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
Angew Chem Int Ed Engl. 2020 Dec 1;59(49):21899-21903. doi: 10.1002/anie.202008564. Epub 2020 Sep 30.
A robust platform is developed to assemble sub-10 nm organic aggregation-induced emission (AIE) particles using four different AIE luminogens (AIEgens) with emissions from green to the second near-infrared window (NIR-II). They are called AIE quantum dots (QDs) to distinguish from typical AIE dots which are larger than 25 nm. Compared with AIE dots that are larger than 25 nm, AIE QDs allow more efficient cellular uptake and imaging without surface modification of any membrane-penetrating peptides or other targeting molecules. NIR-II AIEgens, which have nearly no background fluorescence from organisms, are used to demonstrate that AIE QDs can achieve high contrast at the tumor as small as 80 mm and evade the liver more efficiently than AIE dots. AIE QDs hold a good promise for sensitive and precise diagnosis of the latent solid tumor in clinical medicine with much lower off-targeting to the liver than AIE dots.
我们开发了一个强大的平台，用于组装亚 10nm 的有机聚集诱导发射（AIE）粒子，使用了四种不同的具有从绿色到第二近红外窗口（NIR-II）发射的 AIE 发光体（AIEgens）。它们被称为 AIE 量子点（QDs），以与大于 25nm 的典型 AIE 点区分开来。与大于 25nm 的 AIE 点相比，AIE QDs 无需对任何穿透细胞膜的肽或其他靶向分子进行表面修饰，就可以更有效地被细胞摄取和成像。由于生物体几乎没有背景荧光，因此使用近红外二区（NIR-II）AIEgens 来证明 AIE QDs 可以在小至 80mm 的肿瘤中实现高对比度，并比 AIE 点更有效地逃避肝脏。与 AIE 点相比，AIE QDs 对肝脏的非靶向性要低得多，有望在临床医学中实现对潜伏性实体瘤的灵敏和精确诊断。
