College of Metrology and Measurement Engineering, China Jiliang University, Hangzhou, 310000, People's Republic of China.
College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310000, People's Republic of China.
Mikrochim Acta. 2023 Jun 10;190(7):256. doi: 10.1007/s00604-023-05838-4.
In recent years, nanomaterials have attracted the research intervention of experts in the fields of catalysis, energy, biomedical testing, and biomedicine with their unrivaled optical, chemical, and biological properties. From basic metal and oxide nanoparticles to complex quantum dots and MOFs, the stable preparation of various nanomaterials has always been a struggle for researchers. Microfluidics, as a paradigm of microscale control, is a remarkable platform for online stable synthesis of nanomaterials with efficient mass and heat transfer in microreactors, flexible blending of reactants, and precise control of reaction conditions. We describe the process of microfluidic preparation of nanoparticles in the last 5 years in terms of microfluidic techniques and the methods of microfluidic manipulation of fluids. Then, the ability of microfluidics to prepare different nanomaterials, such as metals, oxides, quantum dots, and biopolymer nanoparticles, is presented. The effective synthesis of some nanomaterials with complex structures and the cases of nanomaterials prepared by microfluidics under extreme conditions (high temperature and pressure), the compatibility of microfluidics as a superior platform for the preparation of nanoparticles is demonstrated. Microfluidics has a potent integration capability to combine nanoparticle synthesis with real-time monitoring and online detection, which significantly improves the quality and production efficiency of nanoparticles, and also provides a high-quality ultra-clean platform for some bioassays.
近年来，纳米材料以其无与伦比的光学、化学和生物学特性，吸引了催化、能源、生物医学检测和生物医学等领域专家的研究干预。从基本的金属和氧化物纳米颗粒到复杂的量子点和 MOFs，各种纳米材料的稳定制备一直是研究人员的奋斗目标。微流控技术作为微尺度控制的范例，是在微反应器中进行纳米材料在线稳定合成的卓越平台，具有高效的质量和热量传递、反应物的灵活混合以及反应条件的精确控制。我们根据微流控技术和微流控对流体的操控方法，描述了过去 5 年中纳米颗粒的微流体制备过程。然后，介绍了微流控技术制备不同纳米材料的能力，如金属、氧化物、量子点和生物聚合物纳米颗粒。微流控技术还能够有效合成一些具有复杂结构的纳米材料，并在高温和高压等极端条件下制备纳米材料的案例，展示了微流控技术作为纳米材料制备的优越平台的兼容性。微流控技术具有强大的集成能力，可将纳米颗粒合成与实时监测和在线检测相结合，显著提高了纳米颗粒的质量和生产效率，同时也为一些生物测定提供了高质量的超净平台。
