Buyukaydin Banu, Guler Eray Metin, Karaaslan Tahsin, Olgac Atilla, Zorlu Mehmet, Kiskac Muharrem, Kocyigit Abdurrahim
Department of Internal Medicine, Bezmialem Vakif University Medical Faculty, İstanbul 34093, Turkey.
Department of Medical Biochemistry, Bezmialem Vakif University Medical Faculty, İstanbul 34093, Turkey.
World J Diabetes. 2020 Jul 15;11(7):309-321. doi: 10.4239/wjd.v11.i7.309.
Diabetic polyneuropathy is a very common complication of diabetes. Numerous studies are available in terms of pathogenesis. But examination methods with low reliability are still not standardized and generally time consuming. High-sensitive, easy-to-access methods are expected. Biochemical markers are one of the subjects of research. We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy.
To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder.
A total of 392 patients with type 2 diabetes mellitus were included in the study. The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination. The biochemical parameters, oxidative stress markers, visfatin, and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs.
Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration ( < 0.005). Neuropathy related symptoms were present in 20.7% of the patients, but neuropathy related findings were observed in 43.9% of the patients. Serum glucose, glycated hemoglobin, and visfatin were positively correlated with each other. Also, these parameters were positively correlated with the total oxidative stress index. Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status. Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status ( < 0.005). There was no correlation between visfatin and thiol-disulphide ( = 0.092, = 0.086). However, a significant negative correlation was observed between visfatin and total with native thiol ( < 0.005, = -0.338), ( < 0.005, = -0.448).
Diagnosis of neuropathy is one of the issues studied in patients with diabetes. Visfatin and thiol-disulfide balance were analyzed for the first time in this study with inspiring results.
糖尿病性多发性神经病变是糖尿病非常常见的并发症。关于其发病机制已有大量研究。但可靠性较低的检查方法仍未标准化且通常耗时较长。人们期待高敏感性、易于采用的方法。生化标志物是研究课题之一。我们旨在发现一种可用于尚未出现神经病变症状的糖尿病患者的潜在生物标志物。
确定内脂素及硫醇 - 二硫化物内稳态在此病症中的地位及可用性。
本研究共纳入392例2型糖尿病患者。采用主观周围神经病变筛查问卷和密歇根神经病变筛查工具问卷及检查对多发性神经病变临床体征进行评估。分析生化参数、氧化应激标志物、内脂素及硫醇 - 二硫化物内稳态，并相互关联以及与临床体征进行关联分析。
主观周围神经病变筛查问卷和密歇根神经病变筛查工具问卷的检查评分相互关联且与糖尿病病程相关（<0.005）。20.7%的患者存在神经病变相关症状，但43.9%的患者观察到神经病变相关体征。血清葡萄糖、糖化血红蛋白和内脂素相互呈正相关。此外，这些参数与总氧化应激指数呈正相关。总硫醇和天然硫醇与总抗氧化状态呈正相关，与氧化状态呈负相关。相反，硫醇 - 二硫化物与较高的葡萄糖和氧化状态呈正相关，与总抗氧化状态呈负相关（<0.005）。内脂素与硫醇 - 二硫化物之间无相关性（P = 0.092，r = 0.086）。然而，内脂素与总硫醇和天然硫醇之间观察到显著负相关（<0.005，r = -0.338），（<0.005，r = -0.448）。
神经病变的诊断是糖尿病患者研究的问题之一。本研究首次分析了内脂素和硫醇 - 二硫化物平衡，结果令人鼓舞。
