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并发钙化防御和 COVID-19 相关血栓性网状青斑。

Concomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura.

机构信息

Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.

Department of Radiology, Weill Cornell Medicine, 525 E. 68th Street, New York, NY, 10065, USA.

出版信息

Skeletal Radiol. 2020 Nov;49(11):1879-1884. doi: 10.1007/s00256-020-03579-6. Epub 2020 Aug 26.

DOI:10.1007/s00256-020-03579-6
PMID:32844243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7447529/
Abstract

While initial reports regarding coronavirus disease 2019 (COVID-19) focused on its pulmonary manifestations, more recent literature describes multisystem abnormalities related to its associated microvascular angiopathy. Calciphylaxis is a rare systemic condition characterized by tissue necrosis in the setting of systemic microvascular calcifications. Both COVID-19 and calciphylaxis are procoagulant diagnoses associated with vascular-mediated cutaneous findings. To our knowledge, this is the first report to document the coexistence of COVID-19 associated retiform thrombotic purpura and calciphylaxis in a single patient, to link the pathologic etiologies of the two entities, and to describe the concomitant diagnoses' associated radiologic findings.

摘要

虽然最初关于 2019 年冠状病毒病(COVID-19)的报告主要集中在其肺部表现,但最近的文献描述了与相关微血管病相关的多系统异常。钙化性尿毒症性小动脉病是一种罕见的系统性疾病,其特征是在系统性微血管钙化的情况下发生组织坏死。COVID-19 和钙化性尿毒症性小动脉病都是与血管介导的皮肤表现相关的促凝诊断。据我们所知,这是第一份报告记录了 COVID-19 相关网状血栓性紫癜和钙化性尿毒症性小动脉病在单个患者中共存,将这两个实体的病理病因联系起来,并描述了同时存在的诊断相关的放射学发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a715/7447529/7d170eeac4f9/256_2020_3579_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a715/7447529/7cc6ba7380cf/256_2020_3579_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a715/7447529/56f2018e6de8/256_2020_3579_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a715/7447529/7d170eeac4f9/256_2020_3579_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a715/7447529/7cc6ba7380cf/256_2020_3579_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a715/7447529/56f2018e6de8/256_2020_3579_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a715/7447529/7d170eeac4f9/256_2020_3579_Fig3_HTML.jpg

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引用本文的文献

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Redefining Calciphylaxis as a Uniquely Bone Forming Subcutaneous C5b-9-Mediated Microvascular Injury Syndrome Associated With Localized Subcutaneous and Systemic Complement Pathway Activation.重新定义钙化防御为一种独特的骨形成性皮下 C5b-9 介导的微血管损伤综合征,与局部皮下和全身补体途径激活有关。
Am J Dermatopathol. 2024 Dec 1;46(12):807-818. doi: 10.1097/DAD.0000000000002783. Epub 2024 Sep 17.
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Calciphylaxis: An Unusual and Silent Usher for an Underlying Carcinoma.钙过敏症:一种隐匿的潜在癌症异常先兆
Cureus. 2023 Nov 6;15(11):e48363. doi: 10.7759/cureus.48363. eCollection 2023 Nov.
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Calciphylaxis and its co-occurrence with connective tissue diseases.

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Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.严重 COVID-19 感染发病机制中的补体相关微血管损伤和血栓形成:五例报告。
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钙化防御及其与结缔组织病的共同发生。
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Nonuremic Calciphylaxis Precipitated by COVID-19 Infection.由新冠病毒感染引发的非尿毒症性钙化防御
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The skin as a critical window in unveiling the pathophysiologic principles of COVID-19.皮肤作为揭示 COVID-19 病理生理原理的关键窗口。
Clin Dermatol. 2021 Nov-Dec;39(6):934-965. doi: 10.1016/j.clindermatol.2021.07.001. Epub 2021 Jul 22.
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Dermatological Manifestations Associated with COVID-19 Infection.与新型冠状病毒肺炎感染相关的皮肤表现
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Int J Clin Pract. 2021 Dec;75(12):e14720. doi: 10.1111/ijcp.14720. Epub 2021 Sep 28.
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Skin Health Dis. 2021 Jun;1(2):e20. doi: 10.1002/ski2.20. Epub 2021 Mar 19.
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