Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.
Department of Radiology, Weill Cornell Medicine, 525 E. 68th Street, New York, NY, 10065, USA.
Skeletal Radiol. 2020 Nov;49(11):1879-1884. doi: 10.1007/s00256-020-03579-6. Epub 2020 Aug 26.
While initial reports regarding coronavirus disease 2019 (COVID-19) focused on its pulmonary manifestations, more recent literature describes multisystem abnormalities related to its associated microvascular angiopathy. Calciphylaxis is a rare systemic condition characterized by tissue necrosis in the setting of systemic microvascular calcifications. Both COVID-19 and calciphylaxis are procoagulant diagnoses associated with vascular-mediated cutaneous findings. To our knowledge, this is the first report to document the coexistence of COVID-19 associated retiform thrombotic purpura and calciphylaxis in a single patient, to link the pathologic etiologies of the two entities, and to describe the concomitant diagnoses' associated radiologic findings.
虽然最初关于 2019 年冠状病毒病(COVID-19)的报告主要集中在其肺部表现,但最近的文献描述了与相关微血管病相关的多系统异常。钙化性尿毒症性小动脉病是一种罕见的系统性疾病,其特征是在系统性微血管钙化的情况下发生组织坏死。COVID-19 和钙化性尿毒症性小动脉病都是与血管介导的皮肤表现相关的促凝诊断。据我们所知,这是第一份报告记录了 COVID-19 相关网状血栓性紫癜和钙化性尿毒症性小动脉病在单个患者中共存,将这两个实体的病理病因联系起来,并描述了同时存在的诊断相关的放射学发现。