Division of Prevention and Community Health, National Center for Cardiovascular Disease, National Clinical Research center of Cardiovascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 102308, China.
State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Sci Total Environ. 2020 Dec 20;749:141588. doi: 10.1016/j.scitotenv.2020.141588. Epub 2020 Aug 10.
Along with global climate change, the relationship between temperature variability (TV) and cardiovascular hospitalization and deaths have been well established. However, limited studies were conducted to reveal the underlying mechanism for TV-related cardiovascular diseases.
In the current study, a novel TV calculation, taking account for both interday and intraday TV as well as lag effects, was used to investigate the effect of short-term TV on the level of high-sensitivity C reactive protein (hs-CRP), which is a crucial preclinical predictor for cardiovascular disease (CVD).
Among the 11,623 Chinese population (46.0% male; mean age 49.8 years), the average hs-CRP was 1.4 mg/ L (standard deviation 1.6 mg/L). Statistical significance between TV and hs-CRP was observed for different TV exposure days (TV01-TV07) in adjusted model, with highest effect for TV06. Specifically, per 1 °C increase in TV06 led to 2.241% (95%CI: 1.552%-2.935%) increase in hs-CRP. Female, obesity and elderly population were more susceptible to TV. The largest mediator for the association of TV and hs-CRP was lipoprotein(a), accounting for 8.68%, followed by smoking status (4.78%), alcohol use (3.95%) and systolic BP (3.20%).
Short-term TV will significantly increase the level of hs-CRP, suggesting hs-CRP to be the potential biologic mechanisms underlying the cardiovascular effects of TV. And more attention should be paid to unstable weather in the global climate change context. Further developing efficient public health policies on climate change may benefit for global heath.
随着全球气候变化，温度变化（TV）与心血管住院和死亡之间的关系已得到充分证实。然而，目前的研究还很少揭示 TV 与心血管疾病相关的潜在机制。
本研究采用一种新的 TV 计算方法，同时考虑了日间和日内 TV 以及滞后效应，旨在研究短期 TV 对高敏 C 反应蛋白（hs-CRP）水平的影响，hs-CRP 是心血管疾病（CVD）的重要临床前预测指标。
在 11623 名中国人群（46.0%为男性；平均年龄 49.8 岁）中，hs-CRP 的平均水平为 1.4mg/L（标准差 1.6mg/L）。在调整模型中，不同 TV 暴露天数（TV01-TV07）的 TV 与 hs-CRP 之间存在统计学意义，TV06 的影响最大。具体而言，TV06 每升高 1°C，hs-CRP 增加 2.241%（95%CI：1.552%-2.935%）。女性、肥胖和老年人群对 TV 更敏感。TV 与 hs-CRP 之间的主要中介因素是脂蛋白（a），占 8.68%，其次是吸烟状况（4.78%）、饮酒（3.95%）和收缩压（3.20%）。
短期 TV 会显著增加 hs-CRP 水平，提示 hs-CRP 可能是 TV 对心血管系统影响的潜在生物学机制。在全球气候变化背景下，应更加关注不稳定的天气。进一步制定有关气候变化的有效公共卫生政策可能有益于全球健康。
