KIST Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.
KIST Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.
Food Res Int. 2020 Oct;136:109495. doi: 10.1016/j.foodres.2020.109495. Epub 2020 Jun 27.
Despite the previously reported health benefits of calcium intake for the attenuation of metabolic disease, few studies have investigated the relationships among calcium intake, gut microbiota, and host metabolism. In this study, we assessed the effects of calcium supplementation on host microbial community composition and metabolic homeostasis. Mice were fed a high-fat diet with different calcium concentrations (4 and 12 g/kg) of 2 calcium supplements, calcium carbonate and calcium citrate. Supplementation with the higher concentration of calcium citrate significantly prevented body weight gain and decreased plasma biomarkers for metabolic disorder compared to calcium carbonate supplementation. Both calcium supplementation led to changes in microbial composition, increased propionate production and increased anorexigenic GLP-1 gene expression. The calcium citrate groups also experienced less metabolic endotoxemia. Our findings suggested that calcium supplementation could ameliorate host metabolic disorder caused by a high-fat diet, due to gut microbiota changes as well as decreased intestinal inflammation.
尽管先前有研究报道钙摄入有益于减轻代谢疾病，但很少有研究调查钙摄入、肠道微生物群和宿主代谢之间的关系。在这项研究中，我们评估了钙补充对宿主微生物群落组成和代谢稳态的影响。用两种钙补充剂（碳酸钙和柠檬酸钙）以不同的钙浓度（4 和 12 g/kg）喂养高脂肪饮食的小鼠。与碳酸钙补充相比，补充更高浓度的柠檬酸钙可显著防止体重增加和降低代谢紊乱的血浆生物标志物。两种钙补充剂都导致了微生物组成的变化，增加了丙酸的产生，并增加了厌食性 GLP-1 基因的表达。柠檬酸钙组也经历了较少的代谢内毒素血症。我们的研究结果表明，钙补充可以改善高脂肪饮食引起的宿主代谢紊乱，这是由于肠道微生物群的变化以及减少了肠道炎症。
